Dynamic Kinetic Resolution of Acyclic Allylic Acetates Using Lipase and Palladium

Asymmetric Synthesis of Bicyclic Diol Derivatives through Metal and Enzyme Catalysis: Application to the Formal Synthesis of Sertraline

“…The addition of organic solvents such as acetone and methanol to improve the solubility of 7 b did not improve the reaction. Instead, a method developed by Kim and co-workers [18] was employed in which CALB is used to catalyze the transesterification of 7 b in an organic solvent. Kim and co-workers [18] used THF as the solvent, whereas we found that toluene gave the best result.…”

“…Instead, a method developed by Kim and co-workers [18] was employed in which CALB is used to catalyze the transesterification of 7 b in an organic solvent. Kim and co-workers [18] used THF as the solvent, whereas we found that toluene gave the best result. Also, the loading of CALB could be decreased from 377 to only 25 mg mmol À1 .…”

Atom transfer radical cyclization (ATRC) applied to a chemoenzymatic synthesis of Quercus lactones

“…For the dynamic kinetic resolution of allylic substrates, both ruthenium 31 and palladium complexes 32 On the basis of these latter data, we run the hydrolysis of (±)-7 in the presence of 5% PdCl 2 (PhCH 2 CN) 2 . The result was disappointing, as the racemic substrate was converted, under these conditions into (S)-(+)-7 but with a modest 69% ee (Table 4).…”

Approaches based on enzyme mediated kinetic to dynamic kinetic resolutions: A versatile route for chiral intermediates

“…Kim and co-workers [93] have carried out the DKR of acyclic substrates employing Pd(0) based racemization catalyst along with the lipase-catalyzed transesterification (Scheme 27).…”