The floating platform is a critical component of the floating offshore wind turbine (FOWT), and its internal structure design plays a key role in ensuring the safe operation of the FOWT. In this study, the local model of the floating platform was firstly parameterized, and a response surface model was obtained by conducting an orthogonal test. The response surface model was then optimized using a gradient descent algorithm. Finally, the internal structure arrangement was validated through a safety calibration. The optimization results indicate that the maximum stress of the optimized model is reduced by 22.12% compared to the original model, while maintaining the same mass, centroid, and other mass-related parameters. The optimization significantly improves the safety of the structure and provides valuable references for the design and construction of a FOWT platform.