Dynamic mechanisms of cardiac oxygenation during brief ischemia and reperfusion

Parsons, William J.; Rembert, Judith C.; Bauman, Robert P.; Greenfield, Joseph C.; Piantadosi, Claude A.

doi:10.1152/ajpheart.1990.259.5.h1477

Cited by 23 publications

(28 citation statements)

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“…The reproducibility of changes in optical density to a given intervention in a given subject was determined in preliminary studies where handgrip at 45% maximal voluntary contraction (MVC), lower body negative pressure (LBNP) at Ϫ 20 mmHg, and forearm circulatory arrest (to obtain the TLS) was performed twice on four subjects. The differences (mean Ϯ SD) in the change in optical density between the two tests were (cyt a,a 3 The near infrared spectrophotometer, which was constructed in Dr. Claude Piantadosi's laboratory (53)(54)(55), consists of four GaAIAs laser diodes and circuitry for photodetection, demodulation, and logarithmic amplification of the optical signals. The four lasers in sequence provide pulses of monochromatic light (1.5-nm bandwidth) at 775, 810, 870, and 904 nm.…”

Section: In Vivo Near Infrared Multiwavelength Spectroscopymentioning

confidence: 99%

Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle.

Hansen¹,

Thomas²,

Harris³

et al. 1996

J. Clin. Invest.

118

174

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Metabolic products of skeletal muscle contraction activate metaboreceptor muscle afferents that reflexively increase sympathetic nerve activity (SNA) targeted to both resting and exercising skeletal muscle. To determine effects of the increased sympathetic vasoconstrictor drive on muscle oxygenation, we measured changes in tissue oxygen stores and mitochondrial cytochrome a,a 3 redox state in rhythmically contracting human forearm muscles with near infrared spectroscopy while simultaneously measuring muscle SNA with microelectrodes. The major new finding is that the ability of reflex-sympathetic activation to decrease muscle oxygenation is abolished when the muscle is exercised at an intensity Ͼ 10% of maximal voluntary contraction (MVC). During high intensity handgrip (45% MVC), contractioninduced decreases in muscle oxygenation remained stable despite progressive metaboreceptor-mediated reflex increases in SNA. During mild to moderate handgrips (20-33% MVC) that do not evoke reflex-sympathetic activation, experimentally induced increases in muscle SNA had no effect on oxygenation in exercising muscles but produced robust decreases in oxygenation in resting muscles. The latter decreases were evident even during maximal metabolic vasodilation accompanying reactive hyperemia.We conclude that in humans sympathetic neural control of skeletal muscle oxygenation is sensitive to modulation by metabolic events in the contracting muscles. These events are different from those involved in either metaboreceptor muscle afferent activation or reactive hyperemia. ( J. Clin. Invest. 1996. 98:584-596.)

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Section: In Vivo Near Infrared Multiwavelength Spectroscopymentioning

confidence: 99%

Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle.

Hansen¹,

Thomas²,

Harris³

et al. 1996

J. Clin. Invest.

118

174

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“…This latter approach is a long way from clinical application, but progress has been made using near infrared (NIR) spectroscopy in assessing myocardial function [77].…”

Section: Supply-dependencymentioning

confidence: 99%

Beyond the lung: oxygen delivery and tissue oxygenation

Soni¹,

Fawcett²,

Halliday³

1993

Anaesthesia

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“…The technique of near-infrared spectroscopy (NIRS) has been used for non-invasive measurements of cerebral [2-51 and more recently renal blood flow [6, 71 and flap monitoring [8, 91; however, its use to date in cardiology has been limited [ 10,111. The method of NIRS in cardiology is dependent on the light absorption properties of two key biochemical components, namely haemoglobin and myoglobin [2, 3, 81.…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Measurement of Cardiac Oxygenation and Haemodynamics during Transient Episodes of Coronary Artery Occlusion and Reperfusion in the Pig

et al. 1996

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1. The non-invasive method of near-infrared spectroscopy was used to measure myocardial oxygenation and haemodynamics in response to left anterior descending coronary artery occlusion in a porcine model. 2. Near-infrared spectroscopy measures changes in haemoglobin (and myoglobin) oxygenation and blood volume to yield information on tissue perfusion and flow. It also measures the redox state of cytochrome aa3, thus providing information about intracellular oxygen utilization. 3. Left anterior descending coronary artery occlusion was induced to produce periods of ischaemia lasting between 24s and 13.5 min (n = 13). The changes in deoxyhaemoglobin, oxyhaemoglobin and cytochrome aa3 measured during occlusion were all highly significant compared with baseline variation. In all occlusions (n = 13) a rapid decrease in oxyhaemoglobin concentration (-75.83 +/- 3.27 mumol/l, mean +/- SEM) with a simultaneous increase in deoxyhaemoglobin of 9.27 +/- 1.69 mumol/l was measured. The total haemoglobin concentration also fell by -71.3 +/- 5.32 mumol/l. Cytochrome aa3 was also reduced during occlusion (-8.35 +/- 1.044) mumol/l. 4. Over the range 24-60s occlusion, the magnitude of the fall in total haemoglobin and oxyhaemoglobin correlated with the duration of occlusion (P < 0.003 and 0.013 respectively). For total haemoglobin only the magnitude of the fall correlated with the increase upon release of occlusion (r = 0.89, P < 0.003). 5. Release of occlusion (n = 8) resulted in an immediate increase in the concentration of deoxyhaemoglobin at 9.88 +/- 1.06s, then total haemoglobin at 13.62 +/- 1.23s and finally oxyhaemoglobin at 29.75 +/- 5.96s. The difference between the timing of the maxima after reperfusion is significant (P < 0.002 and P < 0.007 respectively). Moreover, the time for the deoxyhaemoglobin signal to reach maximum values was found to correlate with the duration of occlusion (P < 0.04). This could be indicative of the PO2 of the ischaemic tissues and an immediate off-loading of oxygen from oxyhaemoglobin. The results are reliable, reproducible and sensitive enough to detect the kinetics of haemoglobin oxygenation from a beating heart in situ.

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Dynamic mechanisms of cardiac oxygenation during brief ischemia and reperfusion

Cited by 23 publications

References 0 publications

Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle.

Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle.

Beyond the lung: oxygen delivery and tissue oxygenation

Non-Invasive Measurement of Cardiac Oxygenation and Haemodynamics during Transient Episodes of Coronary Artery Occlusion and Reperfusion in the Pig

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