This paper’s objective and novelty is to understand the impact of different natural ventilation strategies as well as the effect of a proposed smart controlled ventilation strategy on cooling energy saving and thermal comfort in a residential building. Afterwards, an investigation of the Climatic Potential of Natural Ventilation (CPNV) in hot and dry climates, and particularly the potential of the night ventilation strategy under present and future climates, was made. Two prediction climate change scenarios, RCPs 2.6 and 8.5, were considered for two periods. The results, obtained by a validated simulation, have shown the beneficial effect of night ventilation, since it could reduce cooling load by 9% and would keep the operative temperature below 30°C. Nevertheless, the potential of this natural ventilation strategy would be reduced in the future due to climate change. Indoor overheating has been projected to increase drastically. The summer thermal behaviour will be greatly aggravated in the future. Indeed, the CPNV in the summer nights will be decreased by 25%. However, the climate change will affect the winter natural ventilation potential in the future. The results also highlighted that the annual Total Climatic Potential of Natural Ventilation could be increased by 1% for RCP 2.6 and decreased by 4.9% for RCP 8.5.