With the application of new-generation information technology in the full life cycle process of a complex product, it is showing the characteristics of multi-source, real-time, heterogeneous, cross-domain transmission. Large data volume and low value density emerge in the process of complex product design manufacturing and services (DMS). This leads to “information islands” and insufficient utilization of cross-domain reliability data in the process of integration of DMS for complex product R&D design data, manufacturing data and operation and maintenance services (O&MS) data. This paper proposes and illustrates a framework of complex product DMS integration based on reliability data, including complex product design optimization based on manufacturing and service reliability data, complex product intelligent manufacturing process optimization based on real-time reliability data and complex product O&MS optimization based on multi-source heterogeneous reliability data. Additionally, it then realizes complex product design reliability and optimization, manufacturing process reliability and optimization and O&MS reliability and intelligent decision optimization based on reliability data. Finally, the DMS integration framework based on reliability-data-driven proposal is corrected through the case of engine MDS integration, which can effectively improve the cross-domain reliability data utilization and overall product reliability of complex products. The proposed framework extends the application of reliability theory in the process of complex product DMS integration and provides a reference for enterprises in the R&D, manufacturing and O&MS of complex products.