In China, the maximum design speed of highways is 120 km/h, which first appeared in the Highway Engineering Technical Standard (Trial) in 1951. However, vehicle performance, road design, and construction technology have been greatly improved over the past 68 years. To adapt to the development demands of highway design speeds above 120 km/h in the future, it is urgent to study superhighway alignment design theory. Therefore, the horizontal alignment security design theory of superhighways was developed in this paper. First, the definition, classification, and construction mode of a superhighway and suitable vehicles of different grades are presented. Then, the lengths of straight lines were limited to reduce driving fatigue. Next, the minimum radii of circular curves were calculated based on driver characteristics and stress analysis of operating vehicles. Finally, the minimum lengths of transition curves were calculated based on the centrifugal acceleration of the operating vehicles, the travel time, and the passenger visual characteristics. The calculation and analysis results show that the superhighway linear features conform to the vehicle operating characteristics, and can ensure the safety of driving.