Dynamic Monitoring of Changes in Fecal Flora of Giant Pandas in Mice: Co-Occurrence Network Reconstruction

Gan, Baoxing; Sun, Ning; Lai, Jing; Wan, Zhiqiang; Li, Lianxin; Wang, Yanyan; Zeng, Yan; Zeng, Dong; Pan, Kangcheng; Fang, Jing; Shu, Gang; Wang, Hesong; Xin, Jinge

doi:10.1128/spectrum.01991-22

Cited by 1 publication

(1 citation statement)

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“…The prevalence of gastrointestinal disorders caused by pathogenic bacteria poses a major threat to the well-being of giant pandas [1][2][3]. In recent decades, the use of antimicrobial drugs has become a common practice in safeguarding the health of captive giant pandas against infectious diseases [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Bamboo Consumption on the Spread of Antibiotic Resistance Genes in Giant Pandas

Yan,

He,

Ayala

et al. 2023

Veterinary Sciences

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The spread of antibiotic resistance genes (ARGs) in the environment exacerbates the contamination of these genes; therefore, the role plants play in the transmission of resistance genes in the food chain requires further research. Giant pandas consume different bamboo parts at different times, which provides the possibility of investigating how a single food source can affect the variation in the spread of ARGs. In this study, metagenomic analysis and the Comprehensive Antibiotic Resistance Database (CARD) database were used to annotate ARGs and the differences in gut microbiota ARGs during the consumption of bamboo shoots, leaves, and culms by captive giant pandas. These ARGs were then compared to investigate the impact of bamboo part consumption on the spread of ARGs. The results showed that the number of ARGs in the gut microbiota of the subjects was highest during the consumption of bamboo leaves, while the variety of ARGs was highest during the consumption of shoots. Escherichia coli, which poses a higher risk of ARG dissemination, was significantly higher in the leaf group, while Klebsiella, Enterobacter, and Raoultella were significantly higher in the shoot group. The ARG risk brought by bamboo shoots and leaves may originate from soil and environmental pollution. It is recommended to handle the feces of giant pandas properly and regularly monitor the antimicrobial and virulence genes in their gut microbiota to mitigate the threat of antibiotic resistance.

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