The deterioration of asphalt pavements caused by moisture is a significant concern for asphalt pavement construction companies. To improve this characteristic, this research aims to determine how rejuvenators and flexible compounds, affect the resistance of asphalt concrete to moisture. This study investigates the effects of incorporating Waste Engine Oil (WEO), an easily obtainable and economical substance, into a maturing mixture. The action of this substance resulted in strengthening the physical and chemical characteristics of the bitumen, as well as mitigating the adverse effects caused by moisture. The various degrees of bitumen penetration ranged from 40-50 to 80-1. Extremely small limestone dust particles measuring 19.0 mm, were utilized as mineral infill in the aggregate grade. To enhance the Marshall characteristics, treatments containing 0%, 2%, 4%, and 6% WEO by weight of binder were implemented after filtration. The most advanced Marshall had a WEO content of 6% and an asphalt grade ranging from 85-100, while stability and resistance to moisture degradation were observed. Compared to combinations lacking WEO, the compressive strength and the indirect tensile strength value, were determined to find the Index of Retained Strength (IRS) and Tensile Strength Ratio (TSR). This reduced moisture susceptibility as TSR% and IRS% values increased by approximately 1.22% and 0.9%, respectively.