Dynamic monitoring of transmembrane potential changes: a study of ion channels using an electrical double layer-gated FET biosensor

Pulikkathodi, Anil Kumar; Sarangadharan, Indu; Chen, Yi Hong; Lee, Geng Yen; Chyi, Jen‐Inn; Lee, Gwo‐Bin; Wang, Yu Lin

doi:10.1039/c7lc01305a

Cited by 18 publications

(27 citation statements)

References 34 publications

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“…They further demonstrated that the device could achieve single-cell resolution and measure the bioelectric signals with high sensitivity in physiological salt concentrations. [105] Recently, electric currents and potentials have been measured in vivo in a triple-negative breast cancer tumor model using vibrating probes and glass microelectrodes. [106] Traditional methods of measuring bioelectricity are validated procedures that have been used to generate some significant data related to bioelectricity changes in cancer cells as compared to normal cells.…”

Section: Detecting and Monitoring Tumors Based On Electrical Activitymentioning

confidence: 99%

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Robinson

Jain

Sherman

et al. 2021

Advanced Therapeutics

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Bioelectronic medicine is a treatment modality that uses electricity to treat disease by altering the body's electrical communication systems. All cells are electrically active, in that they possess bioelectric circuitry generating a resting membrane potential and endogenous electric fields that influence cell functions and communication. There is now an accepted paradigm that cancer is characterized by malfunctions in cells' bioelectrical circuitry. This yields opportunities for bioelectronic medicine as novel treatments for cancer by manipulating its bioelectrical properties. To highlight the possibilities a bioelectrical approach can offer cancer therapy, the relevance of bioelectrical activity in cancer is reviewed and also how such activity can be hijacked in novel treatments. This includes sensing or measuring the electrical activity of cells for diagnostic and prognostic applications, controlling or altering bioelectricity including both ionic and faradaic current processes, and eliciting morphological changes using electric fields. Importantly, key links between cellular ionic and faradaic processes that contribute to cancer phenotypes are presented, which if considered and understood as a whole, can bring broad-reaching improvements to cancer therapy.

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Section: Detecting and Monitoring Tumors Based On Electrical Activitymentioning

confidence: 99%

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Robinson

Jain

Sherman

et al. 2021

Advanced Therapeutics

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“…Biosensors based on the electrical double layer gated AlGaN/GaN high electron mobility transistors were used to dynamically monitor changes in the transmembrane potential, as reported by Lee, Wang, and co-workers [110]. Here, circulating tumor cells of colorectal cancer together with cellular bioelectric signals were investigated.…”

Section: Reviewmentioning

confidence: 99%

Review of advanced sensor devices employing nanoarchitectonics concepts

Ariga¹,

Makita²,

Watanabe³

et al. 2019

Beilstein J. Nanotechnol.

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Many recent advances in sensor technology have been possible due to nanotechnological advancements together with contributions from other research fields. Such interdisciplinary collaborations fit well with the emerging concept of nanoarchitectonics, which is a novel conceptual methodology to engineer functional materials and systems from nanoscale units through the fusion of nanotechnology with other research fields, including organic chemistry, supramolecular chemistry, materials science and biology. In this review article, we discuss recent advancements in sensor devices and sensor materials that take advantage of advanced nanoarchitectonics concepts for improved performance. In the first part, recent progress on sensor systems are roughly classified according to the sensor targets, such as chemical substances, physical conditions, and biological phenomena. In the following sections, advancements in various nanoarchitectonic motifs, including nanoporous structures, ultrathin films, and interfacial effects for improved sensor function are discussed to realize the importance of nanoarchitectonic structures. Many of these examples show that advancements in sensor technology are no longer limited by progress in microfabrication and nanofabrication of device structures – opening a new avenue for highly engineered, high performing sensor systems through the application of nanoarchitectonics concepts.

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“…A very impressive work was also published by Pulikkathodi et al in 2018 [ 76 ]. The authors developed a methodology where the EDL formed on a metallic gate electrode was used to modulate the channel conductivity of an electrical double layer FET (EDLFET).…”

Section: Devicesmentioning

confidence: 93%

“… Structure of the electrical double layer FET (EDLFET), using AlGaN as a semiconductor, with and without the passivation layer (to better see the structure). Adapted from Pulikkathodi et al [ 76 ], with permission of The Royal Society of Chemistry. …”

Section: Figurementioning

confidence: 99%

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Transistors for Chemical Monitoring of Living Cells

2018

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Featured Application Animal testing will be soon replaced by better accepted and less expensive in-vitro cell culture models, which explains the recent demand for real-time cell culture monitoring systems. They can bring high throughput screening and could be used not only for biomedical purposes (drug discovery, toxicology, protein expression, cancer diagnostic, etc.), but also for environmental ones (qualification of pollutants cocktails, for example). Beyond this, in-situ monitoring also participates in strengthening the fundamental knowledge about cells metabolism. AbstractWe review here the chemical sensors for pH, glucose, lactate, and neurotransmitters, such as acetylcholine or glutamate, made of organic thin-film transistors (OTFTs), including organic electrochemical transistors (OECTs) and electrolyte-gated OFETs (EGOFETs), for the monitoring of cell activity. First, the various chemicals that are produced by living cells and are susceptible to be sensed in-situ in a cell culture medium are reviewed. Then, we discuss the various materials used to make the substrate onto which cells can be grown, as well as the materials used for making the transistors. The main part of this review discusses the up-to-date transistor architectures that have been described for cell monitoring to date.

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Dynamic monitoring of transmembrane potential changes: a study of ion channels using an electrical double layer-gated FET biosensor

Cited by 18 publications

References 34 publications

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Review of advanced sensor devices employing nanoarchitectonics concepts

Transistors for Chemical Monitoring of Living Cells

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