Dynamic MR Findings of Ductal Carcinoma in Situ within a Fibroadenoma

Kato, Fumiki; Omatsu, Takashige; Matsumura, Wakana; Takahashi, Masato; Hosoda, Mitsuchika; Takahashi, Hiromasa; Kubota, Kanako; Oyama‐Manabe, Noriko; Terae, Satoshi; Shirato, Hiroki

doi:10.2463/mrms.10.129

Cited by 13 publications

(16 citation statements)

References 7 publications

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“…Imaging studies may suggest characteristics of carcinomas arising from fibroadenomas [14–16]. In sonographic examination of fibroadenomas, irregular shape and contour, extensive hypo-echogenicity, shadowing, echogenic halo and distortion of surrounding tissue are considered to be hints of suspicious malignancy [15].…”

Section: Discussionmentioning

confidence: 99%

“…On mammography, irregular shape, ill-defined spiculated margins or pleomorphic/linear micro-calcifications should also be considered signs of malignancy [14]. With dynamic MRI, benign fibroadenoma and DCIS/IDC can be differentiated according to differences in vascularity [16]. Parameter colour maps can also demonstrate the extent of DCIS within a fibroadenoma [16].…”

Section: Discussionmentioning

confidence: 99%

“…With dynamic MRI, benign fibroadenoma and DCIS/IDC can be differentiated according to differences in vascularity [16]. Parameter colour maps can also demonstrate the extent of DCIS within a fibroadenoma [16]. However, in the case described here, sonography, mammography and MRI revealed a well-defined, sharply circumscribed hypoechoic lesion with increased vascularity (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Fibroadenoma progress to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis? Report an unusual case

Chen

et al. 2017

Journal of Surgical Case Reports

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Fibroadenoma of the breast is the most common benign neoplasm in young women who present with a palpable, movable mass. Malignancy inside fibroadenomas is rare, with reported rates ranging from 0.002% to 0.125%. Carcinoma in situ inside a fibroadenoma is usually found incidentally when tumours are excised. Whether fibroadenoma is a risk factor for breast cancer remains controversial. Due to the rarity of carcinomas inside fibroadenomas, medical institutes have little experience with this phenomenon. We report an unusual case in which progression occurred from benign fibroadenoma to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis. A nipple-areolar complex-preserving mastectomy with immediate breast reconstruction with a gel implant and contralateral augmentation was performed. No local recurrence or metastasis was found during 5 years of follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fibroadenoma progress to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis? Report an unusual case

Chen

et al. 2017

Journal of Surgical Case Reports

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“…Typically, on MRI, fibroadenoma appears as a round or oval-shaped mass with a smooth margin. Fibroadenoma can exhibit variable enhancement; however, enhancement usually persists until the delayed phase ( 4 ). Only few reports described DCE-bMRI findings of carcinoma within fibroadenoma.…”

Section: Discussionmentioning

confidence: 99%

Radiologic Findings of Ductal Carcinoma in Situ Arising Within a Juvenile Fibroadenoma: Mammographic, Sonographic and Dynamic Contrast-Enhanced Breast MRI Features

et al. 2014

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Juvenile fibroadenoma is an uncommon histologic variant of fibroadenoma that frequently shows a remarkable and rapid growth. The development of a carcinoma within a fibroadenoma, either in situ or invasive, is a rare condition. We encountered a 36-year-old woman with a palpable mass in the right breast. The radiologic findings were indicative of a fibroadenoma in the breast. Sonographic guided biopsy using a 14G core needle revealed the presence of ductal carcinoma in situ (DCIS) within the juvenile fibroadenoma. Focal excision was performed and the patient underwent radiation therapy in the right breast after surgery.

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“…1 The mammographic features of carcinoma originating within a fibroadenoma include round, oval or lobulated mass, margin irregularity, suspicious linear or pleomorphic calcifications. 12 Fibroadenomas are seen as a focal round or oval shaped mass with smooth margins at MRI 12 . In our case radiologic imaging was reported as irregular countoured, heterogeneous hypoechoic mass with fibrotic shrinkage around at USG.…”

Section: Discussionmentioning

confidence: 99%

Invasive Breast Carcinoma Occuring Within Fibroadenoma: Case Report

Dandin¹,

Karakaş²,

Balta³

et al. 2015

Turkiye Klinikleri J Case Rep

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A AB BS ST TR RA AC CT T Fibroadenomas are the most common benign tumors of the breast. Carcinomas occuring within fibroadenoma are very rare. Fibroadenomas present in approximately 10% of women at autopsy, also occurs 20% of all the benign breast mass and usually identified as circumscribed masses at physical examination or mammography. The most common histologic type is lobular carcinoma in situ, followed by ductal carcinoma in situ, invasive ductal carcinoma and invasive lobular carcinoma. Positive family history, complex fibroadenomas, proliferative disease adjacent fibroadenomas and BRCA mutation are the risk factors for malign transformation within fibroadenomas. Histopathological examination should be performed routinely to rule out malignancy because of no definitive clinical or radiological criteria for diagnosing carcinoma occuring within fibroadenoma. We presented a case of invasive breast carcinoma occuring within fibroadenoma.K Ke ey y W Wo or rd ds s: : Fibroadenoma; carcinoma, ductal; carcinoma, lobular Ö ÖZ ZE ET T Fibroadenomlar memenin en sık benign tümörleridir. Fibroadenomadan kanser gelişimi oldukça nadirdir. Fibroadenoma, genellikle fizik muayene ve mamografide sınırlı kitleler olarak tanımlanıp, kadınların otopsisinde yaklaşık %10 oranında saptanırken tüm iyi huylu meme kitlelerinin % 20'sini oluşturur. En sık görülen histolojik tip lobular karsinoma in situdur, bunu duktal karsinoma in situ, invaziv duktal karsinom, invazif lobüler karsinom takip eder. Pozitif aile öyküsü, karmaşık fibroadenomalar, fibroadenomaya komşu proliferatif hastalık ve BRCA mutasyonu fibroadenomanın malign transformasyonu için risk faktörleridir. Fibroadenomadan karsinom gelişiminin tanısında kesin bir klinik ve radyolojik kriter olmadığından maligniteyi dışlamak için histopatolojik değerlendirme yapılmalıdır. Burada fibroadenomadan gelişen invaziv meme kanserli bir olguyu sunmaktayız.A An na ah ht ta ar r K Ke el li im me el le er r: : Fibroadenom; karsinom, duktal; karsinom, lobüler T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J C Ca as se e R Re ep p 2 20 01 15 5; ;2 23 3( (2 2) ): :1 14 49 9--5 52 2

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Dynamic MR Findings of Ductal Carcinoma in Situ within a Fibroadenoma

Cited by 13 publications

References 7 publications

Fibroadenoma progress to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis? Report an unusual case

Fibroadenoma progress to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis? Report an unusual case

Radiologic Findings of Ductal Carcinoma in Situ Arising Within a Juvenile Fibroadenoma: Mammographic, Sonographic and Dynamic Contrast-Enhanced Breast MRI Features

Invasive Breast Carcinoma Occuring Within Fibroadenoma: Case Report

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