Dynamic MR Imaging of Breast Lesions: Correlation with Microvessel Distribution Pattern and Histologic Characteristics of Prognosis

Teifke, A.; Behr, Oliver; Schmidt, M.; Victor, Anja; Vomweg, T. W.; Thelen, M.; Lehr, Hans‐Anton

doi:10.1148/radiol.2392050205

Cited by 129 publications

(84 citation statements)

References 36 publications

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“…However, the arteriovenous connection was observed to cause a perfusion shortcut (22), which supports the results of the present study.…”

Section: Discussionsupporting

confidence: 92%

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Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation

Chen

et al. 2016

Molecular and Clinical Oncology

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Abstract. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a novel imaging modality that can be used to reflect the microcirculation, although its value in diagnosing rectal cancer is unknown. The present study aimed to explore the clinical application of DCE-MRI in the preoperative diagnosis of rectal cancer, and its correlation with tumor differentiation. To achieve this, 40 pathologically confirmed patients with rectal cancer and 15 controls were scanned using DCE-MRI. The Tofts model was applied to obtain the perfusion parameters, including the plasma to extravascular volume transfer (Ktrans), the extravascular to plasma volume transfer (Kep), the extravascular fluid volume (Ve) and the initial area under the enhancement curve (iAUC). Receiver-operating characteristic (ROC) curves were plotted to determine the diagnostic value. The results demonstrated that the time-signal intensity curve of the rectal cancer lesion exhibited an outflow pattern. The Ktrans, Kep, Ve, and iAUC values were higher in the cancer patients compared with controls (P<0.05). The intraclass correlation coefficients of Ktrans, Kep, Ve and iAUC, as measured by two independent radiologists, were 0.991, 0.988, 0.972 and 0.984, respectively (all P<0.001), indicating a good consistency. The areas under the ROC curves for Ktrans and iAUC were both >0.9, resulting in a sensitivity and specificity of 100% and 93.3% for Ktrans, and of 92.5%, and 93.3% or 100%, for iAUC, respectively. In the 40 rectal cancer cases, there was a moderate correlation between Ktrans and iAUC, and pathological differentiation (0.365 years old, and rectal cancer occurs rarely in patients who are under 40 years of age; in addition, men are predominantly affected (2). Probable risk factors include age, male gender, colon polyps, a history of colorectal cancer, a history of inflammatory bowel disease, hereditary syndromes, lifestyle factors (diet, alcohol, obesity, sedentary lifestyle and smoking), and a history of diabetes mellitus (1). Rectal cancer is usually managed using a combination of surgery, chemotherapy, targeted therapy and radiation therapy (3). The five-year survival rates following surgical resection are 85-95% for stage I, 60-80% for stage II, and 30-60% for stage III cancer. With the aging of the Chinese society and a Westernization of the diet, the incidence of rectal cancer in China is increasing (4). Therefore, finding novel means to efficiently detect and diagnose rectal cancer are required.Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a relatively novel imaging modality that demonstrates the capillary blood flows (5,6). In DCE-MRI, the distribution of the contrast agent is repeatedly evaluate...

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“…However, the arteriovenous connection was observed to cause a perfusion shortcut (22), which supports the results of the present study.…”

Section: Discussionsupporting

confidence: 92%

“…The most commonly used DCE-MRI parameter that reflects vascular permeability is Ktrans (the volume transfer constant) (16,22). Ktrans represents the rate at which the contrast agent transfers from the blood to the interstitium, which indicates the tumor microcirculation and the surface infiltration area.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation

Chen

et al. 2016

Molecular and Clinical Oncology

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“…The relationship between breast cancer vascularity and results of imaging techniques detecting tumour angiogenesis has also been studied by otherresearchers [26,28,29,30].FortheCESMtechnique,Dormainet al [27]reportedastatisticallyinsignificanttrendtowardhigherintratumouralBVD in breast cancer patients with true-positive results ascomparedtofalse-negatives.Thisresultissimilar toours:fortrue-positivecancerpatients(wedidnot find false-negatives) we found significantly higher BVD in carcinomas with medium/strong enhancementinCESM.Thediscrepancybetweentheaforementionedresultsmightbetheeffectofthesmaller numberofcasesreportedbyDormainet al [27]and a different method of BVD assessment. A significant positive correlation between BVD and lesion enhancementinmagneticresonancewasalsoreported [28,29,30].However,nocorrelationwasfound betweenenhancementandLVD [28].…”

Section: Discussionmentioning

confidence: 99%

Correlation between blood and lymphatic vessel density and results of contrast-enhanced spectral mammography

Łuczyńska¹,

Niemiec²,

Ambicka³

et al. 2015

pjp

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“…The enhancement is due to a number of biologic factors, including an increase in vessel number and size, increased vascular permeability, and increased cellularity [17,18]. Maurice et al [19][20][21] reported that morphological criteria have less false positive diagnoses of malignant lesions than of kinetic criteria [19][20][21].…”

Section: Mri Featuresmentioning

confidence: 99%

Something as Simple and as Complex as Fibrocystic Masthopathy Review of MRI Findings in a Case Report

Fernadez¹

2017

IJRRT

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Purpose: conduct a review of the findings on MRI of fibrocystic breast disease, taking into account existing short bibliography about it, from a complex case registered in our service.Discussion: A large part of both clinical and subclinical lesions found in our daily work are benign and correspond with fibrocystic changes (FCC). This entity is complex and part exhibit traits that define characteristically in MRI and diagnose correctly, but there is another small group of changes that can take the image aspect of cancer. From a complex case, we review the main aspects of the FCC in MRI face to better understand a very common condition, although, but at the same time unknown in MRI technique.Conclusion: more than 50% of lesions we see in the context of FCC show morphological and kinetic criteria of malignancy, so in the present moment we cannot avoid biopsies. The most relevant features in MRI in the FCC is non-mass regional enhancement and predominantly curves type II. Keywords: Breast; MRI; Mastopathy; Fibrocystic change; FCC; Predominantly; Lump ReviewThis is the case of 39 years old woman, with no family history of breast cancer, with painless palpable lump recently appeared on CSI left breast, without blushing or heat. The patient comes to our Unit to start imaging studies. Mammographic, ultrasonographic and MR breast findings, and anatomo-pathological analysis are described below. In the mammography we can see a left global asymmetry that primarily affects upper quadrants (Figure 1), associating faint and few fine and heterogeneous scattered microcalcifications. Sonographically a mass measuring 47mm, consisting of numerous small and simple cysts grouped, with some ectatic canalicular segments and moderate hyperemia regional (Figure 2) with a hard and stiff behavior in the US-elastography, so additional histological study is made.

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Dynamic MR Imaging of Breast Lesions: Correlation with Microvessel Distribution Pattern and Histologic Characteristics of Prognosis

Abstract: The different enhancement behaviors of malignant and benign breast lesions cannot be explained by MVD alone; however, a low MVD in the center of carcinoma is reflected quantitatively by a high enhancement ratio and qualitatively by rim enhancement, with an implication of adverse prognosis.

Cited by 129 publications

References 36 publications

Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation

Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation

Correlation between blood and lymphatic vessel density and results of contrast-enhanced spectral mammography

Something as Simple and as Complex as Fibrocystic Masthopathy Review of MRI Findings in a Case Report

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