The end wall loss of modern highly loaded low pressure turbine (LPT) has been greatly increased, due to the enhanced secondary flow loss and boundary layer separation loss. Thus, it is of great significance to develop effective flow control strategies to improve the end wall flow condition and aerodynamic performance of modern LPT. This research carried out a numerical investigation on the coupled flow control strategy, which combined non-axisymmetric end wall contouring (NEC) and root tangential lean (RTL), based on a highly loaded LPT cascade (Zweifel = 1.59). Meanwhile, the optimization process was used to get the optimal design parameters of the coupled method NEC&RTL. The results indicate that the optimal coupled configuration can reduce the total pressure loss coefficient by 12.68% and the non-dimensional secondary kinetic energy by 23.91%. Compared with the reference cascade without modification, the coupled method is found to improve the end wall flow conditions: the passage vortex is weakened both in size and strength, mainly attributed to the smaller cross-passage pressure gradient resulting from NEC; the closed separation bubble near end wall and the three-dimensional separation flow before trailing edge are eliminated, due to the great downward pressure gradient near end wall resulting from RTL; and the counter vortex is eliminated and the slender back flow is weakened under the additional coupling flow control effect of NEC&RTL. Therefore, the coupled flow control method can not only highlight the advantages of the independent methods, but also induce external flow control superiorities, demonstrating the application prospect of the coupled flow control strategy on the highly loaded LPT.