Dynamic of SARS-CoV-2 variants circulation in Tunisian pediatric population, during successive waves, from March 2020 to September 2022

Khemiri, Haifa; Mangone, Iolanda; Gdoura, Mariem; Mefteh, Khawla; Chouikha, Anissa; Fares, Wasfi; Lorusso, Alessio; Ancora, Massimo; Pasquale, Adriano Di; Cammà, Cesare; Halima, Samar Ben; Krichen, Henda; Smaoui, Hanen; Boubaker, Ilhem Boutiba Ben; Bahri, Olfa; Touzi, Henda; Sadraoui, Amel; Meddeb, Zina; Hogga, Nahed; Safer, Mouna; Alaya, Nissaf Ben; Triki, Henda; Haddad-Boubaker, Sondes

doi:10.1016/j.virusres.2024.199353

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…The full genome sequencing, sequences analysis and variant assignment were achieved, as previously described, at Pasteur Institute of Tunis and collaborative centers [17].…”

Section: Complete Genome Sequencing and Genome Analysismentioning

confidence: 99%

Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia

Borgi,

Meftah,

Trabelsi

et al. 2024

Viruses

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Due to low susceptibility of coronavirus disease of 2019 (COVID-19) in children, limited studies are available regarding COVID-19 in the pediatric population in Tunisia. The current study evaluated the incidence, clinical characteristics, and outcomes of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection among children hospitalized at Béchir Hamza Children’s Hospital. A retrospective cohort analysis was conducted using the hospital database between March 2020 and February 2022 with children aged ≤15 years with SARS-CoV-2 infection (confirmed by RT-PCR). A total of 327 COVID-19 hospitalized patients with a mean age of 3.3 years were included; the majority were male. Neurological disease (20%) was the most common comorbidity, while fever (95.3%) followed by cough (43.7%) and dyspnea (39.6%) were the most frequent symptoms reported. Severe disease with oxygen requirement occurred in 30% of the patients; 13% were admitted in the Intensive Care Unit. The overall incidence rate of COVID-19 hospitalization (in Tunis governorates) was 77.02 per 100,000 while the inpatient case fatality rate was 5% in the study population. The most prevalent circulating variant during our study period was Delta (48.8%), followed by Omicron (26%). More than 45% of the study population were <6 months and one-fourth (n = 25, 26.5%) had at least one comorbidity. Thus, the study findings highlight the high disease burden of COVID-19 in infants.

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“…The full genome sequencing, sequences analysis and variant assignment were achieved, as previously described, at Pasteur Institute of Tunis and collaborative centers [17].…”

Section: Complete Genome Sequencing and Genome Analysismentioning

confidence: 99%

Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia

Borgi,

Meftah,

Trabelsi

et al. 2024

Viruses

Self Cite

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Evaluation of Vaccination Coverage Against COVID-19 Among Postpartum Women at the Gaspard Kamara Health Center in Senegal in 2020

Leye,

Touré,

Mendy

2024

CAJPH

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The COVID-19 pandemic has shaken the world and the rapid delivery of vaccines against the virus has raised many questions. Doubts have been raised about the effectiveness and safety of the vaccine in pregnant and breastfeeding women, hence the need to assess vaccination coverage of postpartum women at the Gaspard Kamara health center. We therefore carried out a cross-sectional analytical study from May 31 to June 28, 2022 on all women who gave birth at the Gaspard Kamara health center. Exhaustive recruitment was carried out and the data were analyzed using the SSP software version 2022. In total, 235 women participated in the study, with a mean age of 28.22 ± 5.96 years and extremes 16 and 44 years old. More than half of the patients (68.94%) had given birth vaginally. Those with secondary education accounted for 72.34%. Less than a quarter of women (7.23%) tested positive for COVID19 and 96.60% of them received information on the fight against COVID19, with the media being their main source of information. Less than half (40.43%) knew the vaccines available in Senegal, Johnson & Johnson being the best known. The majority of women (82.55%) believe in the effectiveness of vaccination to eradicate the disease. Age (30 years), lack of information on the fight against COVID19, lack of knowledge of the risks of serious forms in FE, knowledge of the availability of the vaccine in Senegal and vaccination of the spouse were statistically associated with vaccination against COVID19 among women in this country. study. Conclusion: The results of this study show the need to strengthen awareness and communication on the effectiveness and safety of vaccines among pregnant women, particularly those under 30 years of age. Let women know that they can be vaccinated at any age and during any trimester of pregnancy and breastfeeding.

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Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022

Soeorg,

Abroi,

Päll

et al. 2024

PLoS ONE

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Purpose We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries. Methods SARS-CoV-2 sequences in 2021–2022 from a nationwide study were included. The proportion of predominant lineages in Estonian regions and among travel-related cases was described by multinomial logistic regression. Simpson’s indices of diversity were compared using linear regression. Dynamics of Bray-Curtis dissimilarity was described by applying fuzzy clustering to non-metrical dimensional scaling results. Results A total of 2,630 sequences from children (<15 years) and 23,031 from adults (≥15 years) were included. The increase in the proportion of Alpha/Delta/Omicron BA.1/BA.2 lineages was delayed in smaller regions (by 3.5–27.5 days). The proportion of Alpha/Delta/Omicron BA.1 increased earlier among travel-related (n = 4,654) than non-travel-related cases (10.5 days). Diversity was lower in non-travel-related than travel-related cases until Delta period by 0.066. Dynamics of lineages and diversity were similar in adults and children. Similarity of lineages was delayed compared to Finland during Alpha/Omicron BA.1/BA.2 periods and different from all neighbouring countries during Delta period. Conclusion SARS-CoV-2 lineages in children and adults were similar. Differences between regions and travel-related cases and varying similarity to neighbouring countries suggest the importance of mobility in the spread.

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Dynamic of SARS-CoV-2 variants circulation in Tunisian pediatric population, during successive waves, from March 2020 to September 2022

Cited by 3 publications

References 40 publications

Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia

Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia

Evaluation of Vaccination Coverage Against COVID-19 Among Postpartum Women at the Gaspard Kamara Health Center in Senegal in 2020

Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022

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