“…Many research studies of the optimal design of the RO system have been reported, including the superstructure-based optimization, − global optimization, , multiobjective optimization, , genetic algorithm-based meta-model, stochastic cost estimation approach, trace substance removal, ,, etc. New design concepts, such as low-salt-rejection reverse osmosis, permeate split (PS) design, ,,, internally staged design (ISD), , energy-efficient reverse osmosis, and batch RO, , could further decrease the water cost or provide large water flux and high energy efficiency.…”