Dynamic Organization of Presynaptic Calcium Channels

Abstract

Biological system is unique in that component biomolecules are self-organized and emerge adaptable, stable and energy-saving functions. To understand the essential condition for reproducing the properties and constructing stable system from unstable flexible components, we are designing artificial muscle using myosin and DNA nanostructure. System size, spatial positioning, degree of intrinsic noise and the mechanical communication in the synthesized muscle can be modulated and we'll observe the internal dynamics and the system behavior at the single molecule resolution. We have developed several novel tools to modulate the system and monitor the internal dynamics with high precision.