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BackgroundAblative fractional photothermolysis serves as an excellent in vivo model for studying wound healing. The advent of non‐invasive imaging devices, such as line‐field confocal optical coherence tomography (LC‐OCT), enhances this model by enabling detailed monitoring of skin wound healing over time. Additionally, artificial intelligence (AI)‐based algorithms are revolutionizing the evaluation of clinical images by providing detailed analyses that are unfeasible manually.ObjectivesThis study aims to assess the value of combining LC‐OCT and AI for evaluating the acute wound healing process in the skin.MethodsThe forearms of participating volunteers were ablated with a CO2 laser in a fractional pattern (7.5 mJ/MTZ) (ClinicalTrials.gov identifier: NCT05614557). To induce observable wound healing differences, two different approved silicone‐based formulations were randomly assigned to two test sites, with a third site left untreated. In vivo LC‐OCT images were obtained at predefined intervals post‐laser treatment, ranging from 1 to 7 days. These images were further analysed using AI algorithms.ResultsLC‐OCT visualization allows for the characterization of the structural reorganization of the skin during wound healing. The additional integration of AI algorithms significantly enhances the evaluation of the efficacy of wound care interventions by providing a deeper understanding of how these interventions improve wound healing. This is particularly valuable for primary care providers and dermatologists, as AI algorithms have proven useful in observing, characterizing and understanding keratinocyte behaviour.ConclusionsThe combination of AI and high‐resolution imaging represents a promising tool for better understanding wound healing, evaluating the efficacy of current wound care interventions and analysing keratinocyte behaviour in detail during the wound healing process.ClinicalTrials.gov IdentifierNCT05614557.
BackgroundAblative fractional photothermolysis serves as an excellent in vivo model for studying wound healing. The advent of non‐invasive imaging devices, such as line‐field confocal optical coherence tomography (LC‐OCT), enhances this model by enabling detailed monitoring of skin wound healing over time. Additionally, artificial intelligence (AI)‐based algorithms are revolutionizing the evaluation of clinical images by providing detailed analyses that are unfeasible manually.ObjectivesThis study aims to assess the value of combining LC‐OCT and AI for evaluating the acute wound healing process in the skin.MethodsThe forearms of participating volunteers were ablated with a CO2 laser in a fractional pattern (7.5 mJ/MTZ) (ClinicalTrials.gov identifier: NCT05614557). To induce observable wound healing differences, two different approved silicone‐based formulations were randomly assigned to two test sites, with a third site left untreated. In vivo LC‐OCT images were obtained at predefined intervals post‐laser treatment, ranging from 1 to 7 days. These images were further analysed using AI algorithms.ResultsLC‐OCT visualization allows for the characterization of the structural reorganization of the skin during wound healing. The additional integration of AI algorithms significantly enhances the evaluation of the efficacy of wound care interventions by providing a deeper understanding of how these interventions improve wound healing. This is particularly valuable for primary care providers and dermatologists, as AI algorithms have proven useful in observing, characterizing and understanding keratinocyte behaviour.ConclusionsThe combination of AI and high‐resolution imaging represents a promising tool for better understanding wound healing, evaluating the efficacy of current wound care interventions and analysing keratinocyte behaviour in detail during the wound healing process.ClinicalTrials.gov IdentifierNCT05614557.
IntroductionLaser technology has fundamentally transformed the landscape of dermatology, offering nuanced solutions for skin rejuvenation and resurfacing. This paper aims to explore the spectrum of laser technologies, from ablative to non‐ablative and fractional lasers, their mechanisms, benefits, and tailored applications for diverse skin conditions. As we delve into the intricacies of each technology, we also consider the scientific advancements that have made these treatments safer and more effective, promising a new horizon in skin rejuvenation.ObjectiveThis comprehensive analysis seeks to evaluate recent advancements in laser technology for skin rejuvenation, focusing on efficacy, safety, and patient satisfaction.MethodsThe selection criteria for studies in this publication focused on recent, peer‐reviewed articles from the last 20 years, emphasizing advancements in laser technologies for skin rejuvenation. Our comprehensive review involved searches in PubMed, Cochrane, Scopus and Google Scholar using keywords like “skin rejuvenation,” “laser technology,” “efficacy,” “safety,” and “dermatology.” This approach focused on inclusion of recent research and perspectives on the efficacy and safety of laser treatments in the field of dermatology.ResultsOur literature review reveals advancements in laser skin resurfacing technologies, notably fractional lasers for minimal downtime rejuvenation, ablative lasers for precise tissue vaporization, and non‐ablative lasers for coagulation effect promoting collagen with reduced recovery. Hybrid and picosecond lasers are highlighted for their versatility and effectiveness in addressing a wide array of skin concerns. The findings also emphasize the development of safer treatment protocols for ethnic skin, significantly reducing risks like hyperpigmentation and scarring, thus broadening the scope of effective dermatological solutions.ConclusionThis extensive review of advancements in laser technologies for skin rejuvenation underscores a remarkable evolution in dermatological treatments, offering an expansive overview of the efficacy, safety, and patient satisfaction associated with these interventions. Furthermore, the exploration of combination treatments and laser‐assisted drug delivery represents a frontier in dermatological practice, offering synergistic effects that could amplify the therapeutic benefits of laser treatments.
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