Dynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during development

Dávila, José Carlos; Olmos, L.; Legáz, Isabel; Medina, Loreta; Guirado, Salvador; Real, M. Ángeles

doi:10.1016/j.jchemneu.2007.06.003

Cited by 33 publications

(22 citation statements)

References 59 publications

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“…However, the current study is the first to demonstrate directly the age bias in the effects of stress on GABAergic regulation of LAT neurons. In rats, BLA parvalbumin-positive interneurons reach maturity at~PND 30 (Berdel and Morys, 2000;Legaz et al, 2005;Davila et al, 2008), which overlapped with the start of our repeated restraint protocol during adolescence. Repeated stress may stunt the final phases of prepubertal GABAergic development leading to greater impact of stress on GABAergic systems in adolescence.…”

Section: Discussionmentioning

confidence: 91%

“…The GABAergic system in the BLA is still developing during the first several weeks postnatal. In rodents, the GABAergic interneuron network and basic GABAergic IPSC kinetics do not reach maturity until~PND 14-28 (Berdel and Morys, 2000;Legaz et al, 2005;Olmos et al, 2005;Davila et al, 2008;Ehrlich et al, 2013). GABA also appears to exert differences in inhibitory regulation at later ages.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Zhang

Rosenkranz

2016

Neuropsychopharmacol

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The adolescent age is associated with lability of mood and emotion. The onset of depression and anxiety disorders peaks during adolescence and there are differences in symptomology during adolescence. This points to differences in the adolescent neural circuitry that underlies mood and emotion, such as the amygdala. The human adolescent amygdala is more responsive to evocative stimuli, hinting to less local inhibitory regulation of the amygdala, but this has not been explored in adolescents. The amygdala, including the lateral nucleus (LAT) of the basolateral amygdala complex, is sensitive to stress. The amygdala undergoes maturational processes during adolescence, and therefore may be more vulnerable to harmful effects of stress during this time period. However, little is known about the effects of stress on the LAT during adolescence. GABAergic inhibition is a key regulator of LAT activity. Therefore, the purpose of this study was to test whether there are differences in the local GABAergic regulation of the rat adolescent LAT, and differences in its sensitivity to repeated stress. We found that LAT projection neurons are subjected to weaker GABAergic inhibition during adolescence. Repeated stress reduced in vivo endogenous and exogenous GABAergic inhibition of LAT projection neurons in adolescent rats. Furthermore, repeated stress decreased measures of presynaptic GABA function and interneuron activity in adolescent rats. In contrast, repeated stress enhanced glutamatergic drive of LAT projection neurons in adult rats. These results demonstrate age differences in GABAergic regulation of the LAT, and age differences in the mechanism for the effects of repeated stress on LAT neuron activity. These findings provide a substrate for increased mood lability in adolescents, and provide a substrate by which adolescent repeated stress can induce distinct behavioral outcomes and psychiatric symptoms.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Zhang

Rosenkranz

2016

Neuropsychopharmacol

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“…For example, we recently showed that the electrophysiological properties of BLA principal neurons mature rapidly from postnatal day (P)7 to P21, including a 10-fold reduction in input resistance and a 3-fold reduction in membrane time constant, suggesting that the sensitivity to synaptic inhibition would also vary greatly ). There are also concurrent changes in the expression and connectivity of GABAergic interneurons in the BLA, including the emergence and maturation of parvalbumin-expressing interneurons between P14 and P30 (Berdel and Moryś 2000;Davila et al 2008). Between P14 and P20, there is a significant increase in the density of GABAergic fibers and a decrease in the density of GABAergic cell bodies in the BLA (Brummelte et al 2007).…”

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confidence: 99%

Postnatal maturation of GABAergic transmission in the rat basolateral amygdala

Ehrlich

Ryan

Hazra

et al. 2013

Journal of Neurophysiology

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“…Developmental changes may contribute to differences in fear conditioning demonstrated in this paper. Differences include thalamic and cortical afferents to BLA [87] and the relative immaturity of inhibitory systems within the BLA in adolescent rats [88,89]. Age-dependent differences in conditioned freezing are unlikely to be due to general differences in locomotion, as adolescent and adult rats displayed similar total travel distance and average speed during the habituation periods in our study.…”

Section: Discussionmentioning

confidence: 80%

Repeated restraint stress enhances cue-elicited conditioned freezing and impairs acquisition of extinction in an age-dependent manner

Zhang

Rosenkranz

2013

Behavioural Brain Research

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Affective disorders are believed to involve dysfunction within the amygdala, a key structure for processing emotional information. Chronic stress may contribute to affective disorders such as depression and anxiety via its effects on the amygdala. Previous research has shown that chronic stress increases amygdala neuronal activity in an age-dependent manner. However, whether these distinct changes in amgydala neuronal activity are accompanied by age-dependent changes in amygdala-dependent affective behavior is unclear. In this study, we investigated how chronic stress impacts amgydala-dependent auditory fear conditioning in adolescent and adult rats in a repeated restraint model. We found that repeated restraint enhanced conditioned freezing in both adolescent and adult rats. But repeated restraint led to impaired acquisition of fear extinction only in adolescent rats. Along with previous findings, these results suggest that chronic stress may precipitate affective disorders via differential mechanisms, with different outcomes at different ages.

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Dynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during development

Cited by 33 publications

References 59 publications

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala

Postnatal maturation of GABAergic transmission in the rat basolateral amygdala

Repeated restraint stress enhances cue-elicited conditioned freezing and impairs acquisition of extinction in an age-dependent manner

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