“…Because of the timedependence and discontinuity of CA-125 between follow-ups, providing a longitudinal measurement up to a specific time and assuming survival up to this time were more pertinent and meaningful to calculate the survival probability at a future moment, given that the patient was still at risk until her last follow-up. 6 Adopting this method, we applied the fitted joint model to the 2 patients in the test set and predicted their future survival probabilities. Specifically, patient 8 was a 38.8-year-old Hispanic woman whose menarche was at the age of 12.9 years, menopause was at the age of 48.7 years, and her CA-125 values over time were 20, 13, 11, 56, 112, and 1789 U/mL as measured at 0, 2.1, 6.8, 14.3, 10.5, and 21.7 months.…”