Dynamic properties of hydrogels and fiber-reinforced hydrogels

Martin, Nicholas; Youssef, George

doi:10.1016/j.jmbbm.2018.06.008

Cited by 59 publications

(27 citation statements)

References 41 publications

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“…Their main feature is the ability to absorb (swell) and retain water inside the macromolecule without dissolving it. Polymer chains in a dry state are in the form of tightly closed "bundles", while under the influence of water molecules, the functional groups present in the chains are solvated and dissociated [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, hydrogel matrices are an indispensable class of materials for biomedical applications due to their high biocompatibility, the ability to absorb water and other fluids in a reversible manner, as well as good mechanical properties within biological tissue [2,4,6]. The water-sorption capacity is attributed to the interaction between water molecules and polar groups, which are present in the polymer matrix.…”

Section: Introductionmentioning

confidence: 99%

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Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Bialik-Wąs

Królicka

2021

Molecules

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Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Bialik-Wąs

Królicka

2021

Molecules

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“…A favorable property of hydrogels is their capacity to grow in contact with a thermodynamically viable solvent [124,125]. At the point when a hydrogel in its underlying state is in contact with dissolvable particles, the latter assaults the hydrogel's surface and infiltrates into the polymeric organization [126]. Solvent molecules penetrate into the polymeric network due to charge repulsion between polymer chains, causing an increase in the polymer volume due to liquid uptake [127].…”

Section: Swelling Propertiesmentioning

confidence: 99%

Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy

Akulo¹,

Adalı

Moyo³

et al. 2022

Polymers

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Glaucoma is extensively treated with topical eye drops containing drugs. However, the retention time of the loaded drugs and the in vivo bioavailability of the drugs are highly influenced before reaching the targeted area sufficiently, due to physiological and anatomical barriers of the eye, such as rapid nasolacrimal drainage. Poor intraocular penetration and frequent administration may also cause ocular cytotoxicity. A novel approach to overcome these drawbacks is the use of injectable hydrogels administered intravitreously for sustained drug delivery to the target site. These injectable hydrogels are used as nanocarriers to intimately interact with specific diseased ocular tissues to increase the therapeutic efficacy and drug bioavailability of the anti-glaucomic drugs. The human eye is very delicate, and is sensitive to contact with any foreign body material. However, natural biopolymers are non-reactive, biocompatible, biodegradable, and lack immunogenic and inflammatory responses to the host whenever they are incorporated in drug delivery systems. These favorable biomaterial properties have made them widely applicable in biomedical applications, with minimal adversity. This review highlights the importance of using natural biopolymer-based intravitreal hydrogel drug delivery systems for glaucoma treatment over conventional methods.

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“…Hydrogels are large polymeric networks that are highly magnified, hydrophilic, and capable of retaining a large amount of water within their pores (Martin & Youssef, 2018 ; Wang, 2018 ). Due to their enhanced biocompatibility, these bioactive resources are commonly used in tissue engineering (Vermonden & Klumperman, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment

Wang

Shao

et al. 2022

Drug Delivery

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The systemic drug has historically been preferred for the treatment of the majority of pathological conditions, particularly liver cancer. Indeed, this mode of treatment is associated with adverse reactions, toxicity, off-target accumulation, and rapid hepatic and renal clearance. Numerous efforts have been made to design systemic therapeutic carriers to improve retention while decreasing side effects and clearance. Following systemic medication, local administration of therapeutic agents allows for higher ‘effective’ doses with fewer side effects, kidney accumulation, and clearance. Hydrogels are highly biocompatible and can be used for both imaging and therapy. Hydrogel-based drug delivery approach has fewer side effects than traditional chemotherapy and can deliver drugs to tumors for a longer time. The chemical and physical flexibility of hydrogels can be used to achieve disease-induced in situ accumulation as well as subsequent drug release and hydrogel-programmed degradation. Moreover, they can act as a biocompatible depot for localized chemotherapy when stimuli-responsive carriers are administrated. Herein, we summarize the design strategies of various hydrogels used for localized chemotherapy of liver cancer and their delivery routes, as well as recent research on smart hydrogels.

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Dynamic properties of hydrogels and fiber-reinforced hydrogels

Cited by 59 publications

References 41 publications

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy

Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment

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