Dynamic Reciprocity: The Role of the Extracellular Matrix Microenvironment in Amplifying and Sustaining Pathological Lung Fibrosis

Burgess, Janette K.; Muizer, Kirsten; Brandsma, Corry‐Anke; Heijink, Hilde

doi:10.1007/978-3-319-98143-7_9

Cited by 3 publications

(3 citation statements)

References 180 publications

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“…The continuous and dynamic interaction between cells and their surrounding environment affects biomechanical and biochemical properties of the ECM and cell function through activation of signal transduction pathways that regulate gene and protein expressions ( Dede Eren et al, 2022 ). The entirety of these bidirectional interactions between cells and their surrounding ECM is referred to as cell–ECM dynamic reciprocity and represents the key driver of most important biological processes such as development and disease, as well as reproduction and embryogenesis ( Thorne et al, 2015 ; Turley et al, 1991 ; Knudson and Peterson, 2004 ; Burgess et al, 2019 ; Nemec and Kilian, 2021 ).…”

Section: Cell–ecm Bidirectional Reciprocity: Implication In Morphogen...mentioning

confidence: 99%

In vitro strategies for mimicking dynamic cell–ECM reciprocity in 3D culture models

Urciuolo

Imparato

Netti

2023

Front. Bioeng. Biotechnol.

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The extracellular microenvironment regulates cell decisions through the accurate presentation at the cell surface of a complex array of biochemical and biophysical signals that are mediated by the structure and composition of the extracellular matrix (ECM). On the one hand, the cells actively remodel the ECM, which on the other hand affects cell functions. This cell–ECM dynamic reciprocity is central in regulating and controlling morphogenetic and histogenetic processes. Misregulation within the extracellular space can cause aberrant bidirectional interactions between cells and ECM, resulting in dysfunctional tissues and pathological states. Therefore, tissue engineering approaches, aiming at reproducing organs and tissues in vitro, should realistically recapitulate the native cell–microenvironment crosstalk that is central for the correct functionality of tissue-engineered constructs. In this review, we will describe the most updated bioengineering approaches to recapitulate the native cell microenvironment and reproduce functional tissues and organs in vitro. We have highlighted the limitations of the use of exogenous scaffolds in recapitulating the regulatory/instructive and signal repository role of the native cell microenvironment. By contrast, strategies to reproduce human tissues and organs by inducing cells to synthetize their own ECM acting as a provisional scaffold to control and guide further tissue development and maturation hold the potential to allow the engineering of fully functional histologically competent three-dimensional (3D) tissues.

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Section: Cell–ecm Bidirectional Reciprocity: Implication In Morphogen...mentioning

confidence: 99%

In vitro strategies for mimicking dynamic cell–ECM reciprocity in 3D culture models

Urciuolo

Imparato

Netti

2023

Front. Bioeng. Biotechnol.

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“…In the pulmonary system, ECM is the main component of basal membrane (type IV collagen and laminin) and lamina propria, and alveolar interstitium (collagens, fibronectin, elastin, and fibronectin) [ 99 , 100 ]. It is thought that fibroblasts and myofibroblasts are the main ECM producers inside the pulmonary niche [ 101 ]. Reconstruction of ECM is tightly regulated by the activity of MMPs and tissue inhibitors of metalloproteinase (TIMPs) [ 102 ].…”

Section: Pathological Changes Following Copdmentioning

confidence: 99%

Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties

et al. 2022

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Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent immune cell infiltration and release of several cytokines contribute to progressive chronic remodeling. Recent investigations have revealed that exosomes belonging to extracellular vesicles are involved in the pathogenesis of COPD. It has been elucidated that exosomes secreted from immune cells are eligible to carry numerous pro-inflammatory factors exacerbating the pathological conditions. Here, in this review article, we have summarized various and reliable information about the negative role of immune cell-derived exosomes in the remodeling of pulmonary tissue and airways destruction in COPD patients.

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“…Mechanical strength is mainly provided by collagen fibres, while elastin fibres provide elasticity [2]. Traditionally, ECM is considered a network for structural support; however, recent findings indicate ECM to be far more bioactive and dynamic – orchestrating biochemical and biomechanical messages that regulate cell behaviour [1,3]. Dynamic remodelling of ECM is essential to preserve tissue homeostasis and dysregulation of ECM remodelling is an emerging research field, especially in cancer and in fibrosis [4–6].…”

Section: Introductionmentioning

confidence: 99%

Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

Vasse

Nizamoglu

Heijink

et al. 2021

The Journal of Pathology

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Fibrosis results from aberrant wound healing and is characterized by an accumulation of extracellular matrix, impairing the function of an affected organ. Increased deposition of extracellular matrix proteins, disruption of matrix degradation, but also abnormal post‐translational modifications alter the biochemical composition and biophysical properties of the tissue microenvironment – the stroma. Macrophages are known to play an important role in wound healing and tissue repair, but the direct influence of fibrotic stroma on macrophage behaviour is still an under‐investigated element in the pathogenesis of fibrosis. In this review, the current knowledge on interactions between macrophages and (fibrotic) stroma will be discussed from biochemical, biophysical, and cellular perspectives. Furthermore, we provide future perspectives with regard to how macrophage–stroma interactions can be examined further to ultimately facilitate more specific targeting of these interactions in the treatment of fibrosis. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.

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Dynamic Reciprocity: The Role of the Extracellular Matrix Microenvironment in Amplifying and Sustaining Pathological Lung Fibrosis

Cited by 3 publications

References 180 publications

In vitro strategies for mimicking dynamic cell–ECM reciprocity in 3D culture models

In vitro strategies for mimicking dynamic cell–ECM reciprocity in 3D culture models

Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties

Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

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