1998
DOI: 10.1128/mcb.18.5.2514
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Dynamic Regulation of Copper Uptake and Detoxification Genes in Saccharomyces cerevisiae

Abstract: The essential yet toxic nature of copper demands tight regulation of the copper homeostatic machinery to ensure that sufficient copper is present in the cell to drive essential biochemical processes yet prevent the accumulation to toxic levels. In Saccharomyces cerevisiae, the nutritional copper sensor Mac1p regulates the copper-dependent expression of the high affinity Cu(I) uptake genes CTR1, CTR3, and FRE1, while the toxic copper sensor Ace1p regulates the transcriptional activation of the detoxification ge… Show more

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Cited by 172 publications
(103 citation statements)
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“…Subsequent hybridization with a LEU2 probe was implemented as an internal control (not shown). Hybridization revealed a 1.9-kb transcript whose expression was not affected by the addition of copper, in agreement with the results described for the S. cerevisiae ACE1 and MAC1 transcripts (10). In the copper-sensitive strain SGSDJ3 does not appear to be a transcript signal, confirming the loss of the CRF1 gene (Fig.…”
Section: Ylcrf1 Transcription Is Not Affected By the Addition Ofsupporting
confidence: 76%
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“…Subsequent hybridization with a LEU2 probe was implemented as an internal control (not shown). Hybridization revealed a 1.9-kb transcript whose expression was not affected by the addition of copper, in agreement with the results described for the S. cerevisiae ACE1 and MAC1 transcripts (10). In the copper-sensitive strain SGSDJ3 does not appear to be a transcript signal, confirming the loss of the CRF1 gene (Fig.…”
Section: Ylcrf1 Transcription Is Not Affected By the Addition Ofsupporting
confidence: 76%
“…Mac1p and Ace1p transcription factors exhibit a number of common features (10). Both share the same N-terminal domain, which is responsible for DNA binding.…”
mentioning
confidence: 99%
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“…Consistent with this idea, several alkaline response genes are transporters, and others are targets of known solute-specific regulatory pathways: CTR3 and FRE1 are targets of the copper-responsive transcription factor Mac1p (46,47); YOR154W is a target of zinc-responsive transcription factor Zap1p (48); PHO11/PHO12 and PHO84 are targets of the phosphate-responsive transcription factor Pho4p (49,50). The fact that Pho11p and Pho12p are acid phosphatases (51) further suggests that their induction by alkaline pH is not a specific response to alkaline conditions.…”
Section: Discussionmentioning
confidence: 66%
“…6B). Finally, OmFET did not restore cell growth of Δctr1/Δctr3, a Cu-uptake deficient strain ( Peña et al, 1998) under copper limiting conditions (data not shown). Altogether, these data suggest that OmFET is an uptake system that could transport iron, zinc, but not copper.…”
Section: Omfet Rescued Growth Of Different Metal Uptake-deficient Yeamentioning
confidence: 99%