2013
DOI: 10.1007/s12522-013-0162-0
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Dynamic regulation of mitochondrial genome maintenance in germ cells

Abstract: Mitochondria play a crucial role in the development and function of germ cells. Mitochondria contain a maternally inherited genome that should be transmitted to offspring without reactive oxygen species-induced damage during germ line development. Germ cells are also involved in the mitochondrial DNA (mtDNA) bottleneck; thus, the appropriate regulation of mtDNA in these cells is very important for this characteristic transmission. In this review, we focused on unique regulation of the mitochondrial genome in a… Show more

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Cited by 13 publications
(9 citation statements)
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“…There are two steps in protecting individuals against the transmission of deleterious mutations to the progeny. One is the elimination of damaged mitochondria to the zygote in a mechanism, which is called bottleneck [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]; the second is lowering mitochondrial activity in the germ-line cells in order to minimize the damage to mitochondrial DNA by the reactive oxygen species (ROS) that are produced during oxidative phosphorylation [ 21 , 66 ]. ROS generate mutations in the mitochondrial DNA (mtDNA) that deteriorates the functions of these organelles [ 25 , 67 , 68 , 70 ] and, in addition, is considered to be the main source of aging [ 37 , 71 , 72 , 73 , 74 , 75 , 76 ].…”
Section: Discussionmentioning
confidence: 99%
“…There are two steps in protecting individuals against the transmission of deleterious mutations to the progeny. One is the elimination of damaged mitochondria to the zygote in a mechanism, which is called bottleneck [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]; the second is lowering mitochondrial activity in the germ-line cells in order to minimize the damage to mitochondrial DNA by the reactive oxygen species (ROS) that are produced during oxidative phosphorylation [ 21 , 66 ]. ROS generate mutations in the mitochondrial DNA (mtDNA) that deteriorates the functions of these organelles [ 25 , 67 , 68 , 70 ] and, in addition, is considered to be the main source of aging [ 37 , 71 , 72 , 73 , 74 , 75 , 76 ].…”
Section: Discussionmentioning
confidence: 99%
“…Together, this provides two levels by which selection might screen for best‐functioning mitochondria. Emerging evidence supports the contention that the mitochondria are active within primordial germ cells and developing oocytes (Ge et al ., ; Kasashima, Nagao & Endo, ; Hayashi et al ., ). Thus, we hypothesize that only those oocytes with full capacity for efficient respiratory function, requiring compatible mitonuclear genotypes, reach maturity (Dumollard, Duchen & Carroll, ; Stewart & Larsson, ).…”
Section: Emerging Themes In Studies Of Mitonuclear Coadaptationmentioning
confidence: 98%
“…In addition to pleiotropic functions, including apoptosis, in mitochondria, PHB1 is required for the organization and stability of mitochondrial nucleoids either through a TFAM-dependent or through a TFAM-independent pathway, in which it regulates nucleoid organization directly or through undefined nucleoid factors [113]. Several reports supported the notion that PHBs are important in mtDNA copy number regulation [103, 113]. …”
Section: Mitochondrial Nucleoid-associating Proteinsmentioning
confidence: 99%