Time-dependent statistical characteristics of load process and strength degradation process are critical to lifetime distribution of series mechanical systems. Conventional rain-flow counting method for lifetime distribution estimation has limited practical application due to its strict requirement for statistical properties of load process. Besides, dynamic interaction between load process and strength degradation process results in strength degradation path dependence (SDPD). SDPD and failure dependence of components jointly bring considerable difficulties in prediction of system lifetime distribution and system residual lifetime distribution. To address these problems, reliability-based analytic models for estimation of whole lifetime distribution and residual lifetime distribution of series mechanical systems under random load are developed in this paper, which take the time-dependent statistical parameters of load process and strength degradation process as the input of the models. Furthermore, SDPD and failure dependence of components are taken into account in the proposed models in an explicit mathematical expression. The results show that SDPD, failure dependence of components, and initial strength dispersion have significant influences on system lifetime distribution.