Dynamic resistance exercise-induced pressor response does not alter hypercapnia-induced cerebral vasodilation in young adults

Sakamoto, Rintaro; Sato, Kohei; Ogoh, Shigehiko; Kamoda, Tatsuki; Neki, Toru; Katayose, Masaki; Iwamoto, Erika

doi:10.1007/s00421-022-05096-x

Cited by 6 publications

(5 citation statements)

References 65 publications

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“…Currently, it is unclear why interval HG does not increase cerebrovascular SR; however, there is one possible mechanism related to P ET CO 2 during interval HG. The previous study (Sakamoto et al., 2023 ) demonstrated that exercise‐induced elevation of P ET CO 2 contributes to an increase in cerebrovascular SR. Actually, increased P ET CO 2 and CBF enhance cerebrovascular SR (Ogoh et al., 2021 ; Smith et al., 2019 ), whereas unchanged P ET CO 2 does not increase cerebrovascular SR during exercise (Sakamoto et al., 2021 ). The lack of change in P ET CO 2 during HG in the present study may be attributed to the small muscle groups involved in the exercise.…”

Section: Discussionmentioning

confidence: 93%

“…However, the direct effects of exercise on cerebrovascular function (e.g., endothelial function) are not well understood. For these reasons, some studies have investigated the acute effect of dynamic exercise on hypercapnia-induced dilatation in the ICA (Sakamoto et al, 2021(Sakamoto et al, , 2022. Sakamoto et al reported that high-intensity aerobic exercise attenuated the hypercapnia-induced dilatation in the ICA at 5 min post-exercise and returned to baseline value at 60 min post-exercise, but moderate-intensity aerobic exercise did not affect it (Sakamoto et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Sakamoto et al reported that high-intensity aerobic exercise attenuated the hypercapnia-induced dilatation in the ICA at 5 min post-exercise and returned to baseline value at 60 min post-exercise, but moderate-intensity aerobic exercise did not affect it (Sakamoto et al, 2021). Accordingly, there is still no evidence that acute exercise can improve cerebrovascular function (Sakamoto et al, 2021(Sakamoto et al, , 2022. In contrast, Iwamoto et al reported that intermittent hypoxia enhances hypercapnia-induced dilatation in the ICA at 25 min post-intervention (Iwamoto et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…How to cite this article: Saito, S., Watanabe, H., Iwamoto, E., & Ogoh, S. (2023). Handgrip exercise does not alter CO 2 -mediated cerebrovascular flow-mediated dilation.…”

Section: Conflict Of Interestmentioning

confidence: 99%

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Handgrip exercise does not alter CO₂‐mediated cerebrovascular flow‐mediated dilation

Saito,

Watanabe,

Iwamoto

et al. 2023

Experimental Physiology

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Handgrip exercise (HG), a small muscle exercise, improves cognitive function and is expected to provide a useful exercise mode to maintain cerebral health. However, the effect of HG on cerebral blood flow regulation is not fully understood. The present study aimed to examine the effect of acute HG on cerebral endothelial function as one of the essential cerebral blood flow regulatory functions. Thirteen healthy young participants performed interval HG, consisting of 4 sets of 2 min HG at 25% of maximum voluntary contraction with 3 min recovery between each set. Cognitive performance was evaluated before and at 5 and 60 min after interval HG using the Go/No‐Go task (reaction time and accuracy). The diameter and blood velocity of the internal carotid artery (ICA) were measured using a duplex Doppler ultrasound system. To assess cerebral endothelial function, hypercapnia (30 s of hypercapnia stimulation, end‐tidal partial pressure of CO2: +9 mmHg)‐induced cerebrovascular flow‐mediated dilatation (cFMD) was induced, calculated as relative peak dilatation from baseline diameter. The shear rate (SR) was calculated using the diameter and blood velocity of the ICA. As a result, cognitive performance improved only at 5 min after interval HG (reaction time, P = 0.008; accuracy, P = 0.186), whereas ICA SR during interval HG and cFMD after interval HG were unchanged (P = 0.313 and P = 0.440, respectively). These results suggest that enhancement in cerebral endothelial function is not an essential mechanism responsible for acute HG‐induced cognitive improvement.New Findings What is the central question of this study? Does handgrip exercise, a small muscle exercise, improve cerebral endothelial function? What is the main finding and its importance? Acute interval isometric handgrip exercise (2 min of exercise at 25% maximum voluntary contraction, followed by 3 min of recovery, repeated for a total of 4 sets) did not improve cerebral endothelial function. Since the cerebrovascular shear rate did not change during exercise, it is possible that acute handgrip exercise is not sufficient stimulation to improve cerebral endothelial function.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…How to cite this article: Saito, S., Watanabe, H., Iwamoto, E., & Ogoh, S. (2023). Handgrip exercise does not alter CO 2 -mediated cerebrovascular flow-mediated dilation.…”

Section: Conflict Of Interestmentioning

confidence: 99%

See 3 more Smart Citations

Handgrip exercise does not alter CO₂‐mediated cerebrovascular flow‐mediated dilation

Saito,

Watanabe,

Iwamoto

et al. 2023

Experimental Physiology

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Less fatiguability in eccentric than concentric repetitive maximal muscle contractions

et al. 2023

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The independent and combined effects of aerobic exercise intensity and dose differentially increase post‐exercise cerebral shear stress and blood flow

Moir,

Corkery,

Miller

et al. 2024

Experimental Physiology

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This research examined the impact of aerobic exercise intensity and dose on acute post‐exercise cerebral shear stress and blood flow. Fourteen young adults (27 ± 5 years of age, eight females) completed a maximal oxygen uptake () treadmill test followed by three randomized study visits: treadmill exercise at 30% of for 30 min, 70% of for 30 min and 70% of for a duration that resulted in caloric expenditure equal to that in the 30% visit (EqEE). A venous blood draw and internal carotid artery (ICA) ultrasound were collected before and immediately following exercise. ICA diameter and blood velocity were determined using automated edge detection software, and blood flow was calculated. Using measures of blood viscosity, shear stress was calculated. Aerobic exercise increased ICA shear stress (time: P = 0.005, condition: P = 0.012) and the increase was greater following exercise at 70% (∆4.1 ± 3.5 dyn/cm2) compared with 30% (∆1.1 ± 1.9 dyn/cm2; P = 0.041). ICA blood flow remained elevated following exercise (time: P = 0.002, condition: P = 0.010) with greater increases after 70% (Δ268 ± 150 mL/min) compared with 30% (∆125 ± 149 mL/min; P = 0.041) or 70% EqEE (∆127 ± 177 mL/min; P = 0.004). Therefore, aerobic exercise resulted in both intensity‐ and dose‐dependent effects on acute post‐exercise ICA blood flow whereby vigorous intensity exercise provoked a larger increase in ICA blood flow compared to light intensity exercise when performed at a higher dose.

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Dynamic resistance exercise-induced pressor response does not alter hypercapnia-induced cerebral vasodilation in young adults

Cited by 6 publications

References 65 publications

Handgrip exercise does not alter CO₂‐mediated cerebrovascular flow‐mediated dilation

Handgrip exercise does not alter CO₂‐mediated cerebrovascular flow‐mediated dilation

Less fatiguability in eccentric than concentric repetitive maximal muscle contractions

The independent and combined effects of aerobic exercise intensity and dose differentially increase post‐exercise cerebral shear stress and blood flow

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Dynamic resistance exercise-induced pressor response does not alter hypercapnia-induced cerebral vasodilation in young adults

Cited by 6 publications

References 65 publications

Handgrip exercise does not alter CO2‐mediated cerebrovascular flow‐mediated dilation

Handgrip exercise does not alter CO2‐mediated cerebrovascular flow‐mediated dilation

Less fatiguability in eccentric than concentric repetitive maximal muscle contractions

The independent and combined effects of aerobic exercise intensity and dose differentially increase post‐exercise cerebral shear stress and blood flow

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Handgrip exercise does not alter CO₂‐mediated cerebrovascular flow‐mediated dilation

Handgrip exercise does not alter CO₂‐mediated cerebrovascular flow‐mediated dilation