<p>This study mainly explores the influence of different seismic incident angles on the damage of irregular bridge track systems in complex topography regions. The seismic ground motions of the V-shaped canyon site were simulated through SH wave theoretical analysis. Nonlinear seismic response analyses of irregular simply supported railway bridge–track systems were performed under the different incident angles of seismic (0°~ 60°). The effects of different seismic incident angles on the seismic response of the bridge-track system are analyzed. The results show that the seismic displacement responses of piers top, transverse movable bearings, and fasteners are significantly different under different seismic incident angles, and the unfavorable seismic incident angle is 60°. Underestimate the maximum 37 % seismic displacement response of pier top, transverse movable bearings, and fastener without considering the influence of incident angle.</p>