Pump-rate regulation is frequently used during hydraulic fracturing operations in order to maintain the pressure within a safe range. An emergency pump-rate reduction or pump shutdown is usually applied under the condition of sand screen-out when advancing hydraulic fractures are blocked by injected proppant and develop wellhead overpressure. The drastic regulation of the pump rate induces water-hammer effects—hydraulic shocks—on the wellbore due to the impulsive pressure. This wellbore shock damages the well integrity and then increases the risk of material leakage into water resources or the atmosphere, depending on the magnitude of the impulsive pressure. Therefore, appropriate emergency pump-rate regulation can both secure the fracturing operation and enhance well-completion integrity for environmental requirements—a rare mutual benefit to both sides of the argument. Previous studies have revealed the tube vibration, severe stress concentration, and sand production induced by water-hammer effects in high-pressure wells during oil/gas production. However, the water-hammer effect, the induced impulsive pressures, and the mitigation measures are rarely reported for hydraulic fracturing injections. In this study, we present a data-driven workflow integrating real-time monitoring and regulation strategies, which is applied in four field cases under the emergency operation condition (screen-out or near screen-out). A stepwise pump-rate regulation strategy was deployed in the first three cases. The corresponding maximum impulsive pressure fell in the range of 3.7~7.4 MPa. Furthermore, a sand screen-out case, using a more radical regulation strategy, induced an impulsive pressure 2 or 3 times higher (~14.7 MPa) than the other three cases. Compared with the traditional method of sharp pump-rate regulation in fields, stepwise pump-rate regulation is recommended to constrain the water-hammer effect based on the evolution of impulsive pressures, which can be an essential operational strategy to secure hydraulic fracturing and well integrity, especially for fracturing geologically unstable formations (for instance, formations near faults).