Dynamic Single-Photon Emission Computed Tomography Data Analysis: Capabilities for Determining Functional Significance of Coronary Artery Atherosclerosis

Мочула, А. В.; Zavadovsky, K. V.; Андреев, С. Л.; Lishmanov, Yu. B.

doi:10.1051/matecconf/20167901080

Cited by 3 publications

(3 citation statements)

References 9 publications

(19 reference statements)

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“…ПЭТ позволяет оценить абсолютные значения миокардиального кровотока (МК) и определить относительную разницу кровоснабжения миокарда в условиях нагрузки и на фоне функционального покоя -показатель резерва коронарного кровотока (РКК). Этот способ оценки микроциркуляции апробирован и хорошо валидизирован [6][7][8]. Однако на данный момент использование ПЭТ для оценки абсолютных показателей перфузии миокарда не нашло широкого применения в клинической практике ввиду сложности и высокой стоимости процедуры [5].…”

Section: Discussionunclassified

“…Другим методом определения абсолютных показателей перфузии -МК и РКК является динамическая однофотонная эмиссионная компьютерная томография (ОФЭКТ) миокарда [6][7][8]. Эта методика появилась относительно недавно, с появлением нового класса гамма-камер, оснащенных полупроводниковыми кадмий-цинк-теллуровыми детекторами (Cadmium-Zinc-Telluride, CZT).…”

Section: Discussionunclassified

“…Подготовка пациентов, протокол исследования, запись и обработка статических и динамических сцинтиграфических данных изложены в предыдущих работах [6,7].…”

Section: динамическая офэкт миокардаunclassified

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Coronary flow reserve in patients with heart failure with preserved ejection fraction

et al. 2022

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Aim. To study the parameters of myocardial blood flow (MBF) and coronary flow reserve (CFR) in patients with heart failure (HF) with preserved ejection fraction and evaluate their relationship with the severity of HF.Material and methods. The study included 47 patients (men, 68,7%) aged 65,0 (58,0; 72,0) years with left ventricular ejection fraction of 62 (56; 67)% and coronary artery stenosis <50%. Serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) were assessed by enzyme immunoassay. MBF and CFR values were assessed using cardiac single photon emission computed tomography.Results. Depending on NT-proBNP levels, the patients were divided into 2 groups (p<0,001): the 1st group included (n=15) patients with NT-proBNP <125 pg/ml (58,2 [41,6; 70,7] pg/ml), while in the 2nd group (n=32) — with NT-proBNP ≥125 pg/ml (511,4 [249,8; 1578,1] pg/ml). The group of patients with high NTproBNP levels was characterized by higher values (by 33,8%, p=0,0001) of resting MBF and reduced CFR (by 14,7%, p=0,001) compared with patients with normal NT-proBNP level: resting MBF — 0,65 (0,44; 0,79) vs 0,43 (0,30; 0,58) ml/min/g; CFR — 2,21 (1,52; 2,83) vs 2,59 (2,47; 3,05), respectively. At the same time, MBF at stress did not differ between the groups. The relationship of NTproBNP levels with global CFR (p=0,012; r=-0,339) and MBF at rest (p=0,012; r=0,322) was established. A stepwise decrease in global CFR was revealed depending on the NYHA class as follows (p<0,001): 2,79 (2,52; 2,93); 1,8 (1,55; 2,08); 1,31 (1,23; 1,49) — for class I, II, and III, respectively.Conclusion. A decrease in CFR in patients with HF with preserved ejection fraction indicates impaired myocardial blood supply, which, in this group of patients, is associated with microcirculatory changes. At the same time, the severity of MBF alterations is closely related to HF severity.

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Coronary flow reserve in patients with heart failure with preserved ejection fraction

et al. 2022

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The myocardial flow reserve in patients with heart failure with preserved ejection fraction

et al. 2022

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Coronary Flow Reserve Assessment in Patients with Cad by Dynamic Single-Photon Emission Computed Tomography

Мочула

Завадовский

Андреев

et al. 2017

Medicinskaâ vizualizaciâ

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Purpose: to assess the coronary flow reserve in patients with one, two and multi-vessel coronary artery diseases by dynamic SPECT using semiconductor (cadmium-zinctelluride)- based gamma camera.Material and methods.This work included 42 patients with stable coronary artery diseases. The first group consisted of 12 (28.6%) patients with single and two-vessel coronary artery disease (STCAD) (8 males and 4 females; mean age 61.5 ± 3.8 years) with intermediate (50–70%) and significant (>70%) coronary artery stenosis. Second group included 30 (71.4%) patients with multi- vessel coronary artery diseases (MVCAD) (22 males and 8 females; mean age 60.1 ± 4.3 years) with a lesion >70% in at least 2 major epicardial vessels according to invasive coronary angiography. All patients underwent rest-stress dynamic SPECT as well as conventional myocardial perfusion imaging with 99mTc-MIBI as a radiopharmaceutical. All scintigraphic images were acquired on the hybrid SPECT/CT unit (GE Discovery NM/CT 570C). Patient with STCAD underwent invasive FFR detection.Results.When comparing the results of MPI between the study groups, there were no significant differences. ROC analysis showed that the global MFR ≤ 1,42 allows to identify MVCAD with a sensitivity and specificity 68% and 86,4%, for PSM, these values are: 39.1% and 86.4% (AUC = 0.655, p < 0.05), respectively (“gold” standard CAG). The sensitivity and specificity of the regional MFR to identify the hemodynamic significance of coronary artery stenoses at a value of <1.33 was 100% (the “gold” standard of FFR). Most likely, high sensitivity and specificity in this case are associated with a small number of patients with true stenoses of FFR.Conclusion.The performance of standard MPI in combination with dynamic single-photon emission computed tomography allows to increase the diagnostic significance of the scintigraphic approach in the evaluation of myocardial microcirculation disorders in multivessel coronary artery disease. Dynamic SPECT is a promising method of noninvasive assessment of hemodynamic significance of coronary artery stenoses.

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Dynamic Single-Photon Emission Computed Tomography Data Analysis: Capabilities for Determining Functional Significance of Coronary Artery Atherosclerosis

Cited by 3 publications

References 9 publications

Coronary flow reserve in patients with heart failure with preserved ejection fraction

Coronary flow reserve in patients with heart failure with preserved ejection fraction

The myocardial flow reserve in patients with heart failure with preserved ejection fraction

Coronary Flow Reserve Assessment in Patients with Cad by Dynamic Single-Photon Emission Computed Tomography

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