“…The persistent, mobile, and toxic (PMT) and very persistent and very mobile (vPvM) substances can persist for a long time and spread in the urban water circulation system, posing threats to sustainable, safe, and healthy drinking water. − With the increasing international attention on PMT/vPvM substances, they are regarded with an equal concern level as persistent, bioaccumulative, and toxic (PBT) and very persistent and very bioaccumulative (vPvB) substances by the German Environment Agency. − The definition of PMT/vPvM substances was updated in 2022 by the European Union classification, labeling, and packaging (CLP) to match the future management of chemicals . The current identification methods for PMT/vPvM substances by traditional experimental analysis remains a huge challenge due to the incapability of the screening emerging contaminants in large scale. , An accurate and robust ready-to-use tool for high-throughput screening of PMT/vPvM substances is urgently needed. , …”