2011
DOI: 10.1007/s11538-010-9615-3
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Dynamic Stabilization in the PU1-GATA1 Circuit Using a Model with Time-Dependent Kinetic Change

Abstract: The PU.1 and GATA1 genes play an important role in the differentiation of blood stem cells. The protein levels expressed by these genes are thought to be regulated by a self-excitatory feedback loop for each gene and a cross-inhibitory feedback loop between the two genes. A mathematical model that captures the dynamical interaction between these two genes reveals that constant levels of self-excitation and cross-inhibition allow the most self-exciting or cross-inhibiting gene to dominate the system. However, s… Show more

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Cited by 3 publications
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