To reasonably evaluate the overall seismic performance of infilled wall frames, a corresponding nonlinear analysis model is constructed with infilled wall frames as the research object. It quantifies the failure levels of structural and non-structural components and proposes a method for extracting structural overall performance indicators. The vulnerability of the case frame structure is analyzed using the Incremental Dynamic Analysis (IDA) method. The results showed that the seismic performance of the infilled wall frame and the ordinary frame met the seismic fortification requirements, and the seismic capacity of the infilled wall frame was better. After implementing a 7-degree seismic fortification, the cumulative probability of basic integrity, minor damage, and moderate damage for infill wall frames reached 99.15 %, surpassing the fortification target of 1.5 g. However, the seismic capacity of ordinary frames was overestimated, as their cumulative probability of basic intact, minor damage, and moderate damage under a 7-degree seismic fortification was 99.7 %. Neglecting its impact, ordinary frames exhibited lower seismic performance compared to other structures, with a basic intact probability of only 48.49 % under frequent earthquake actions at 7 degrees. The research utilizes effective methods for evaluating the seismic vulnerability of infilled wall frames.