Dynamic switching between intrinsic and extrinsic mode networks as demands change from passive to active processing

Riemer, Frank; Gruener, Renate; Bereśniewicz, Justyna; Kazimierczak, Katarzyna; Ersland, Lars; Hugdahl, Kenneth

doi:10.1101/2020.03.18.997031

Cited by 1 publication

(1 citation statement)

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“…This stark synaptic connectivity contrast between ilPFC- and plPFC-driving circuits, may suggest that the claustrum supports discrete network states. Considering that human task-positive and task-negative cortical networks are anti-correlated (Fox et al, 2005; Uddin et al, 2009; Riemer et al, 2020), and that ilPFC and RSC are identified as two major putative nodes of the default mode network in mouse (Stafford et al, 2014), whereas the plPFC and PtA are putative mouse homologs of major nodes in the human fronto-parietal network (Hwang, 2021; Laubach et al, 2018), the present data may support the idea of the claustrum acting as a relay system sculpting defined cortical networks.…”

Section: Discussionmentioning

confidence: 99%

The mouse claustrum synaptically connects cortical network motifs

Qadir

Stewart

Ryzin

et al. 2022

Preprint

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Spatially distant areas of cerebral cortex coordinate their activity into networks that are integral to cognitive processing. A common structural motif of cortical networks is co-activated frontal and posterior cortical regions. Knowledge of the neural circuit mechanisms underlying such widespread inter-areal cortical coordination is lacking. Using anesthetized mouse functional magnetic resonance imaging (fMRI) we discovered that mouse frontal cortical functional connectivity reflects the common cortical network motif in its functional connectivity to posterior cortices, but also demonstrates significant functional connectivity with the claustrum. Exploring whether the claustrum may synaptically support such network architecture, we used a channelrhodopsin-assisted electrophysiological circuit mapping approach to assess the strength of synaptic connectivity of 35 unique frontal cortico-claustral-cortical connections through 1,050 subtype-identified claustrum projection neurons. We observed significant trans-claustral synaptic connectivity from the anterior cingulate cortex and prelimbic prefrontal cortex back to originating frontal cortical regions as well as to posteriorly-lying visual and parietal association cortices contralaterally. The infralimbic prefrontal cortex possessed significant trans-claustral synaptic connectivity with the posteriorly-lying retrosplenial cortex, but to a far lesser degree with visual and parietal association cortices. These data reveal discrete extended cortical pathways through the claustrum that are positioned to support cortical network motifs central to cognitive control functions.

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