Dynamic thermal/acoustic response for human bone materials at different energy levels: A diagnosis approach

Thella, Ashok Kumar; Rizkalla, James; Rathi, Neeraj; Kakani, Monika; Helmy, Ahdy; Salama, Paul; Rizkalla, Maher

doi:10.1016/j.jor.2016.10.005

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…As indicated in the governing Equations (7), (8), and (9) given below, the acoustic pressure, and accordingly, the thermal energy is function of the frequency and magnitude of the acoustic pressure. In our simulation, we considered three different frequencies: 1 MHz, 2…”

Section: Resultsmentioning

confidence: 99%

Photo Acoustic Energy Applications for the Detection of Human Arterial Blockages via Multiple Skin/Bone Layers, a Non-Invasive Approach

Kakani¹,

Rathi²,

Helmy³

et al. 2017

WJCD

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The impact of arterial narrowing/blocking caused by plaque buildup in arteries leads to many life-threatening consequences. This is recognized as a cause in heart attacks and peripheral vascular disease. Diagnosing the illness is only feasible after symptoms have presented to the patient. Currently, the standard for visualizing coronary arteries is through angiography, which may have complications, and impact on the healthcare system. Furthermore, cardiac catheterization may also places high health risks, given its overall invasiveness. Cardiac arrhythmias, infection, and contrast dye nephrotoxicity are recognized complications within this process. Therefore, a noninvasive approach may have potentials to reduce patient complications, finances surrounding healthcare, and more efficient patient care through earlier screening and diagnosing. This research addresses a new approach using photoacoustic (PA) imaging. The transmission properties of atherosclerosis within walls of arteries, can be exploited using photo acoustics, to better visualize and characterize the degree and severity of atherosclerosis. The delivered energy is absorbed by components of the vascular tissue converted into heat, leading to transient thermos elastic expansion, which creates an acoustic emission. The thermal response was analyzed for its fall and recovery times that are attributed to the artery fat type. The control parameters, including the frequency, penetration depth, energy levels, and tissue layer sizes, for multilayered structures were considered. The struc- tures investigated were fatty infiltrate within the artery, blood, bones, and skin, within frequency range from 1 MHz to 3 MHz, and typical tissue sizes in the milli to centimeter range. As high as 14 MPas in the acoustic pressure at 1 MHz, resulted in temperature difference of up to 3.4 K. When the operating frequency was altered to 2 MHz, the temperature changed to 23 K. Furthermore, when the frequency was changed to 3 MHz, the temperature moved to 43 K. The changes in temperatures were for nearly 1 second duration. The results obtained in this study suggest that there is high potential for practical models using flexible substrate with infra-red sensors and acoustic devices.

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Section: Resultsmentioning

confidence: 99%

Photo Acoustic Energy Applications for the Detection of Human Arterial Blockages via Multiple Skin/Bone Layers, a Non-Invasive Approach

Kakani¹,

Rathi²,

Helmy³

et al. 2017

WJCD

Self Cite

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“…These experiments demonstrate that measurement of temperature change enables differentiation between bone types, with the potential to further differentiate between fat and bone for clinical applications such as atherosclerosis (137). Thermal and acoustic energy could also be used with smart, noninvasive sensors to monitor the progression of orthopedic diseases (135) (see the sidebar titled Bone Characterization Through Temperature for additional clinically relevant highlights).…”

Section: Bone Cancer and Osteoporosismentioning

confidence: 91%

“…Investigators have also studied the temperature change of an examined tissue after exposure of laser light to characterize bone structures and pathologies. For example, Thella et al (134,135) and Rizkalla et al (136) conducted COMSOL simulations to assess the difference in electrical, thermal, and acoustic properties of four types of bone tissue: cancellous bone, cortical bone, red bone marrow, and yellow bone marrow (for a detailed view of the temperature change for 1 s, 3 s, and 5 s exposure, see Supplemental Table 3). These experiments demonstrate that measurement of temperature change enables differentiation between bone types, with the potential to further differentiate between fat and bone for clinical applications such as atherosclerosis (137).…”

Section: Bone Cancer and Osteoporosismentioning

confidence: 99%

Photoacoustic Imaging and Characterization of Bone in Medicine: Overview, Applications, and Outlook

González

Bell

2023

Annu. Rev. Biomed. Eng.

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Photoacoustic techniques have shown promise in identifying molecular changes in bone tissue and visualizing tissue microstructure. This capability represents significant advantages over gold standards (i.e., dual-energy X-ray absorptiometry) for bone evaluation without requiring ionizing radiation. Instead, photoacoustic imaging uses light to penetrate through bone, followed by acoustic pressure generation, resulting in highly sensitive optical absorption contrast in deep biological tissues. This review covers multiple bone-related photoacoustic imaging contributions to clinical applications, spanning bone cancer, joint pathologies, spinal disorders, osteoporosis, bone-related surgical guidance, consolidation monitoring, and transsphenoidal and transcranial imaging. We also present a summary of photoacoustic-based techniques for characterizing biomechanical properties of bone, including temperature, guided waves, spectral parameters, and spectroscopy. We conclude with a future outlook based on the current state of technological developments, recent achievements, and possible new directions. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 25 is June 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Dynamic thermal/acoustic response for human bone materials at different energy levels: A diagnosis approach

Cited by 2 publications

References 13 publications

Photo Acoustic Energy Applications for the Detection of Human Arterial Blockages via Multiple Skin/Bone Layers, a Non-Invasive Approach

Photo Acoustic Energy Applications for the Detection of Human Arterial Blockages via Multiple Skin/Bone Layers, a Non-Invasive Approach

Photoacoustic Imaging and Characterization of Bone in Medicine: Overview, Applications, and Outlook

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