Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis

Abstract

This study investigated the thiol-disulphide balance in vaginitis, which is a local inflammatory condition, through the use of a new method. A cross-sectional study involving 82 women (45 women with vaginitis and 37 women in control group) was conducted at Ataturk Education and Research Hospital, Ankara, Turkey from February 2016 to April 2016. Their ages varied between 19-75 years (mean: 42.8±11.6), were incorporated into the study. Thiol-disulphide parameters were measured and the obtained results were compared. The results showed that the serum disulphide level and disulphide/native thiol ratio in the group with vaginitis (p = 0.03 and p = 0.04) and the native thiol/total thiol ratio in the control group was higher (p = 0.03). In this study, it was shown that serum dynamic thiol-disulphide balance in the women with vaginitis had varied. Although vaginitis is a localized infectious inflammatory condition, the increase in the systemic oxidative stress is important. This study is the first article in the literature that investigates the relationship between dynamic thiol-disulphide balance and vaginitis.

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

“…It has been demonstrated that TDH was shifted in favor of oxidative status in preeclampsia, pregnant women diagnosed with idiopathic recurrent pregnancy loss, pregnant women diagnosed with Familial Mediterranean fever, pregnant women with fetal neural tube defects and vaginitis patients [89][90][91][92][93].…”