Dynamic thiol/disulphide homeostasis in vitiligo patients

Aksoy, Mustafa; Çelik, Hakim

doi:10.5114/ada.2018.72856

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…In recent years, thiol-disulfide homeostasis has been studied in various dermatological conditions. Different results have been obtained, but all attest to the role of thiols and disulfides in the oxidant-antioxidant balance and subsequently in disease pathogenesis [ 76 , 77 , 78 ]. Thiols are an important part of the antioxidant system playing an essential role in mechanisms such as apoptosis, activation of signaling pathways, detoxification, etc.…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress in Cutaneous Lichen Planus—A Narrative Review

Georgescu

Mitran

et al. 2021

JCM

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Lichen planus (LP) is a chronic, immune-mediated inflammatory skin condition that mainly affects the skin (cutaneous LP, CLP) and oral mucosa (oral LP, OLP). However, the mechanisms involved in the pathogenesis of the disease are not fully elucidated. Over time, several theories that could explain the appearance of LP lesions have been postulated. The key players in LP pathogenesis are the inflammatory infiltrate consisting of T cells and the proinflammatory cytokines. The cytokines stimulate the production of reactive oxygen species that induce cell apoptosis, a defining element encountered in LP. The lead inquiry triggered by this revolves around the role of oxidative stress in LP development. There are currently numerous studies showing the involvement of oxidative stress in OLP, but in terms of CLP, data are scarce. In this review, we analyze for the first time the currently existing studies on oxidative stress in CLP and summarize the results in order to assess the role of oxidative stress in skin lesions offering a fresher updated perspective.

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Section: Resultsmentioning

confidence: 99%

Oxidative Stress in Cutaneous Lichen Planus—A Narrative Review

Georgescu

Mitran

et al. 2021

JCM

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“…Disruption of this ratio acts a part in the pathogenesis of many inflammatory diseases such as diabetes mellitus, inflammatory arthritis, renal failure, cancer, Parkinson, Alzheimer, multiple sclerosis. Shifting thiol/disulfide balance to disulfide direction was seen in degenerative diseases such as diabetes, obesity, and pneumonia, to thiol direction poses risk factor neoplastic processes such as multiple myeloma, bladder, colon and kidney cancer (27).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of dynamic thiol-disulfide homeostasis on HPV positive-women in progression to cervical intraepithelial lesion

Erin¹,

Tekın²,

KÜÇÜK³

et al. 2022

J Exp Clin Med

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Dynamic thiol disulfide homeostasis (TDH) is critical in cervical carcinogenesis at HPV infection as a sign of antioxidant consumption native and total thiol levels decrease in progress to cervical intraepithelial lesions. TDH is the main actor in signaling pathways, apoptosis, antioxidant and detoxification reactions. In this study, we aimed to evaluate the effect of TDH intraepithelial progression of cervical precancerous lesions on HPV positive women. This was a prospective cross-sectional study. Subjects were selected from newly diagnosed high risk HPV DNA-positive patients. TDH results were calculated as the levels of disulfide, native and total thiol, the ratios of disulfide/total thiol (SS/SH+SS), disulfide/native thiol (SS/SH) and native thiol/total thiol (SH/SH+SS). A total of 146 women were included in the study. Study groups were as group one; control included 66 participants, group two; HPV DNA-positive women without preinvasive cervical lesion included 30 participants and group three; HPV DNA-positive women with preinvasive cervical lesion included 50 participants. Native and total thiol levels were elevated on HPV-positive women without preinvasive cervical lesions. There were no significant differences between groups related to the ratios of SS/SH, SS/ Total SH, SH/ Total SH levels. HPV infection related to oxidative stress has effects on oxidant/antioxidant balance and could be demonstrated in systemic circulation by TDH parameters. Consumption of thiol substances play a role in the cervical neoplastic process, replacement with antioxidants would be a treatment option for HPV infections.

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“…Disruption of this ratio acts a part in the pathogenesis of many in ammatory diseases such as diabetes mellitus, in ammatory arthritis, renal failure, cancer, Parkinson, Alzheimer, multiple sclerosis. Shifting thiol/disul de balance to disul de direction was seen in degenerative diseases such as diabetes, obesity, and pneumonia, to thiol direction poses risk factor neoplastic processes such as multiple myeloma, bladder, colon and kidney cancer (27).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Dynamic Thiol-Disulfide Homeostasis on Hpv Positive-Women in Progression to Cervical Intraepithelial Lesion

Erin¹,

Tekın²,

Kucuk³

et al. 2021

Preprint

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PURPOSE: Dynamic thiol disulfide homeostasis (TDH) is critical in cervical carcinogenesis at HPV infection as a sign of antioxidant consumption native and total thiol levels decrease in progress to cervical intraepithelial lesions. TDH is the main actor in signaling pathways, apoptosis, antioxidant and detoxification reactions. In this study, we aimed to evaluate the effect of TDH intraepithelial progression of cervical precancerous lesions on HPV positive women.METHODS: This was a prospective cross-sectional study. Subjects were selected from newly diagnosed high risk HPV DNA-positive patients. TDH results were calculated as the levels of disulfide, native and total thiol, the ratios of disulfide/total thiol (SS/SH+SS), disulfide/native thiol (SS/SH) and native thiol/total thiol (SH/SH+SS).RESULTS: A total of 146 women were included in the study. Study groups were as group one; control included 66 participants, group two; HPV DNA-positive women without preinvasive cervical lesion included 30 participants and group three; HPV DNA-positive women with preinvasive cervical lesion included 50 participants. Native and total thiol levels were elevated on HPV-positive women without preinvasive cervical lesions. There were no significant differences between groups related to the ratios of SS/SH, SS/ Total SH, SH/ Total SH levels. CONCLUSIONS: HPV infection related to oxidative stress has effects on oxidant/antioxidant balance and could be demonstrated in systemic circulation by TDH parameters. Consumption of thiol substances play role in the cervical neoplastic process, replacement with antioxidants would be a treatment option for HPV infections.

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Dynamic thiol/disulphide homeostasis in vitiligo patients

Cited by 9 publications

References 17 publications

Oxidative Stress in Cutaneous Lichen Planus—A Narrative Review

Oxidative Stress in Cutaneous Lichen Planus—A Narrative Review

Evaluation of dynamic thiol-disulfide homeostasis on HPV positive-women in progression to cervical intraepithelial lesion

Evaluation of Dynamic Thiol-Disulfide Homeostasis on Hpv Positive-Women in Progression to Cervical Intraepithelial Lesion

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