Dynamic tissue engineering scaffolds with stimuli-responsive macroporosity formation

Han, Liang; Lai, Janice H.; Yu, Stephanie; Yang, Fan

doi:10.1016/j.biomaterials.2013.02.051

Cited by 90 publications

(85 citation statements)

References 36 publications

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“…Han et al developed stimuli-responsive porogens from alginate, gelatin, and HA that respond to chelation, temperature, and enzymatic activity (Han et al ., 2013). Here, the alginate porogen was also used to deliver chondrocytes into the hydrogel, and treatment with changes in temperature, EDTA, or hyaluronidase activity released chondrocytes from the alginate components and subsequently increased hydrogel macroporosity (Han et al ., 2013).…”

Section: B Advances In the Processing Of Hydrogel Scaffoldsmentioning

confidence: 99%

“…Here, the alginate porogen was also used to deliver chondrocytes into the hydrogel, and treatment with changes in temperature, EDTA, or hyaluronidase activity released chondrocytes from the alginate components and subsequently increased hydrogel macroporosity (Han et al ., 2013). While this controlled degree of macroporosity affected bulk mechanical properties, approaches have also been developed where mechanics can be dynamically increased with photocrosslinking, such as from 2.6 to 12.5 kPa, without changing porosity (Marklein et al ., 2012).…”

Section: B Advances In the Processing Of Hydrogel Scaffoldsmentioning

confidence: 99%

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Recent advances in hydrogels for cartilage tissue engineering

Vega¹,

Kwon²,

Burdick

2017

eCM

263

176

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Articular cartilage is a load-bearing tissue that lines the surface of bones in diarthrodial joints. Unfortunately, this avascular tissue has a limited capacity for intrinsic repair. Treatment options for articular cartilage defects include microfracture and arthroplasty; however, these strategies fail to generate tissue that adequately restores damaged cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue. To-date, a wide range of scaffolds and cell sources have emerged towards cartilage tissue engineering, with a focus on recapitulating microenvironments present during development or in adult tissue to induce the formation of cartilaginous constructs with biochemical and mechanical properties of native tissue. Hydrogels have emerged as a promising scaffold due to the wide range of properties that are possible and the ability to entrap cells within the material. Towards improving cartilage repair, hydrogel design has advanced in recent years to improve their utility. Some of these advances include the development of improved network crosslinking (e.g., double-networks), new techniques to process hydrogels (e.g., 3D printing), and the better incorporation of biological signals (e.g., controlled release). This review summarizes these innovative approaches to engineer hydrogels towards cartilage repair, with an eye towards eventual clinical translation.

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Section: B Advances In the Processing Of Hydrogel Scaffoldsmentioning

confidence: 99%

Section: B Advances In the Processing Of Hydrogel Scaffoldsmentioning

confidence: 99%

Recent advances in hydrogels for cartilage tissue engineering

Vega¹,

Kwon²,

Burdick

2017

eCM

263

176

View full text Add to dashboard Cite

show abstract

“…Yang and colleagues developed a stimuli-responsive hydrogel which formed macropores in response to different stimuli including temperature, small chelating molecules, and enzymes[243]. The gel was fabricated with a combination of stimuli-responsive porogens of gelatin, alginate, and hyaluronic acid.…”

Section: Microengineering 3d Biomaterials To Study and Direct Cellmentioning

confidence: 99%

Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices

Kilian

2015

Adv Healthcare Materials

131

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Historically the culture of mammalian cells in the laboratory has been performed on planar substrates with media cocktails that are optimized to maintain phenotype. However, it is becoming increasingly clear that much of biology discerned from 2D studies does not translate well to the 3D microenvironment. Over the last several decades, 2D and 3D microengineering approaches have been developed that better recapitulate the complex architecture and properties of in vivo tissue. Inspired by the infrastructure of the microelectronics industry, lithographic patterning approaches have taken center stage because of the ease in which cell-sized features can be engineered on surfaces and within a broad range of biocompatible materials. Patterning and templating techniques enable precise control over extracellular matrix properties including: composition, mechanics, geometry, cell-cell contact, and diffusion. In this review article we will explore how the field of engineered extracellular matrices has evolved with the development of new hydrogel chemistry and the maturation of micro- and nano- fabrication. Guided by the spatiotemporal regulation of cell state in developing tissues, we will review the maturation of micropatterning in 2D, pseudo-3D systems, and patterning within 3D hydrogels in the context of translating the information gained from 2D systems to synthetic engineered 3D tissues.

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“…반응함으로써 물질의 물리/ 화학적 특성이 제어되는 장점이 있으며, 이로 인하여 조직 공학 [1][2][3], 약물 전달 시스템 [4][5][6][7], 바 이오 센서 [4,[8][9][10]] 등 정밀함을 필요로 하는 의료 및 재료산업 분야에 널리 응용되고 있다.…”

Section: 서 론 외부 자극에 응답하는 입자는 미세한 외부 환경의 변화에unclassified

Synthesis of Shape Reconfigurable Janus Particles by External pH Stimuli

Eom¹,

Kim²,

Kang

et al. 2014

Clean Technology

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: This study presents a micromolding for the synthesis of Janus particles with reconfigurable shape by pH stimuli. First, we use acrylic acid (AA) as pH responsive monomer in the hydrophilic part and trimethylolpropane triacylate (TMPTA) in the hydrophobic part, respectively. The change of acidity in solvent induces the swelling of hydrophilic part in the Janus particles. The pH-responsive Janus particles show different swelling ratio of hydrophilic part in according to composition of acrylic acid in diverse range (0-70% v/v) and pH (3-11). As the concentration of acrylic acid in the hydrophilic part and environmental pH increase, the hydrophilic part in the Janus particles is proportionally swelled. Second, we fabricate novel type of Janus particles with two different hydrophilicities. As a proof of concept, we have applied acrylic acid (AA) and 2-(dimethylamino)ethyl methacrylate (DAEMA) into each part because the monomers provide reverse responsive activity. As expected, these Janus particles show different shape anisotropies with reconfigurable property in accordance with the polarity of each part at same acidity of environmental solvent. We envision that the stimuli responsive Janus particles have a wide application from fundamental science to diagnostic apparatus.

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Dynamic tissue engineering scaffolds with stimuli-responsive macroporosity formation

Cited by 90 publications

References 36 publications

Recent advances in hydrogels for cartilage tissue engineering

Recent advances in hydrogels for cartilage tissue engineering

Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices

Synthesis of Shape Reconfigurable Janus Particles by External pH Stimuli

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