Dynamic Ultrasonic Nebulisation Extraction Coupled with Headspace Ionic Liquid‐based Single‐drop Microextraction for the Analysis of the Essential Oil in <i>Forsythia suspensa</i>

Yang, Jinjuan; Wei, Hongmin; Teng, Xiane; Zhang, Hanqi; Shi, Yuhua

doi:10.1002/pca.2490

Cited by 18 publications

(11 citation statements)

References 16 publications

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“…Forsythiae Fructus is also rich in volatiles. A total of fifty-two compounds with anti-inflammatory, anti-oxidant and antimicrobial effects were identified in the oil by GC-MS [ 61 , 62 , 63 , 64 , 65 , 66 ]. β-pinene ( 195 , 45.88%), myrtenol ( 196 , 13.86%), (+)-α-pinene ( 197 , 13.09%), (−)- trans -pinocarveol ( 198 , 7.34%), sabinene ( 199 , 6.64%) and pinocarvone ( 200 , 4.13%) were the major volatiles of Forsythiae Fructus [ 61 ].…”

Section: Phytochemistrymentioning

confidence: 99%

Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics

Zhao

Tong

et al. 2017

Molecules

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Forsythiae Fructus, as a traditional Chinese medicine, has been widely used both as a single herb and in compound prescriptions in Asia, mainly due to its heat-clearing and detoxifying effects. Modern pharmacology has proved Forsythiae Fructus possesses various therapeutic effects, both in vitro and in vivo, such as anti-inflammatory, antibacterial and antiviral activities. Up to now, three hundred and twenty-one compounds have been identified and sensitive analytical methods have been established for its quality control. Recently, the pharmacokinetics of Forsythiae Fructus and its bioactive compounds have been reported, providing valuable information for its clinical application. Therefore, this systematic review focused on the newest scientific reports on Forsythiae Fructus and extensively summarizes its phytochemistry, pharmacology, pharmacokinetics and standardization procedures, especially the difference between the two applied types—unripe Forsythiae Fructus and ripe Forsythiae Fructus—in the hope of providing a helpful reference and guide for its clinical applications and further studies.

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Section: Phytochemistrymentioning

confidence: 99%

Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics

Zhao

Tong

et al. 2017

Molecules

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“…Vahl (Lian-Qiao in Chinese, F. suspense) belongs to the family Oleaceae, which is widely distributed in China, Korea, Japan, and many European nations and is a well-known traditional Chinese medicine [1,2]. It has been used as an antipyretic, antidotal, and anti-inflammatory agent and has been used clinically in China for centuries in the treatment of influenza, pneumonia, ulcers, and acute nephritis [3,4]. It has also been reported that the herb is able to suppress vomiting, resist hepatic injury, inhibit elastase activity, and exhibit diuretic, analegestic, antioxidant, antiendotoxin, and antiviral effects [5,6].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive characterization and quantification of phillyrin in the fruits ofForsythia suspensaand its medicinal preparations by liquid chromatography-ion trap mass spectrometry

Chen

et al. 2016

Acta Chromatographica

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Summary.A rapid and sensitive method for the identification and quantification of phillyrin (POG) in Forsythia suspense is described. The phillyrin standard solution was directly infused into the ion trap mass spectrometers (IT-MS) for collecting the MS n spectra. The electrospray ionization (ESI) mass spectral fragmentation pathway of phillyrin was proposed, and the ESI-MS n fragmentation behavior of phillyrin was deduced in detail. The major product ion at m/z 355 belongs to furofuran, which was formed by loss the glucopyranoside (180 Da), and the characteristic fragment ions m/z 473, 395, 337, 309, and 249 were observed. The loss of 18 Da could arise from two different fragmentation pathways, and the observed ion was composed of a mixture of two different structural ions. Quantification of phillyrin was assigned in positive-ion mode at a product ion at m/z 557 → 355 by liquid chromatography-mass spectrometry (LC-MS). The LC-MS method was validated for linearity, sensitivity, accuracy, and precision and then used to determine the content of the phillyrin. Lastly, the LC-MS method was successfully applied to determine phillyrin in real sample F. suspense and three of its medicinal preparations in the positive mode at the first time.

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“…Thermal desorption of analytes was performed in this case at the GC injection port equipped with a 4-mm i.d. liner filled with glass wool [82].…”

Section: Im][pf 6 ] [75]mentioning

confidence: 99%

Opportunities and shortcomings of ionic liquids in single-drop microextraction

Marcinkowski

Pena‐Pereira

Kloskowski

et al. 2015

TrAC Trends in Analytical Chemistry

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Dynamic Ultrasonic Nebulisation Extraction Coupled with Headspace Ionic Liquid‐based Single‐drop Microextraction for the Analysis of the Essential Oil in Forsythia suspensa

Abstract: The proposed method is environmentally friendly, time saving, with high efficiency and low consumption. It would extend the application range of the HS/SDME and would be useful especially for aromatic plants analysis.

Cited by 18 publications

References 16 publications

Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics

Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics

Comprehensive characterization and quantification of phillyrin in the fruits ofForsythia suspensaand its medicinal preparations by liquid chromatography-ion trap mass spectrometry

Opportunities and shortcomings of ionic liquids in single-drop microextraction

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