Dynamic Viral Severe Acute Respiratory Syndrome Coronavirus 2 RNA Shedding in Children: Preliminary Data and Clinical Consideration from a Italian Regional Center

Ioris, Maria Antonietta De; Scarselli, Alessia; Atti, Marta Luisa Ciofi degli; Ravà, Lucilla; Smarrazzo, Andrea; Concato, Carlo; Romani, Lorenza; Scrocca, Raffaella; Geremia, Caterina; Carletti, Michaela; Carducci, Francesca Ippolita Calò; Bernardi, Stefania; Coltella, Luana; Santilli, Veronica; Chiurchiù, Sara; Peschiaroli, Emanuela; Mariani, Rosanna; Marabotto, Caterina; Perrotta, Daniela; Villani, Alberto; Rossi, Paolo; D’Argenio, Patrizia; Campaña, Andrea; Raponi, Massimiliano

doi:10.1093/jpids/piaa065

Cited by 34 publications

(39 citation statements)

References 14 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[9] Although in our locality, 4 children suffered from such a predicament, cumulatively from our literature review, the number of children who have prolonged faecal excretion and potential spread of infection of SARS-CoV-2 by this route is approximately 150-200 in total. [7,8,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Therefore, this issue is a huge concern affecting many patients and deserves further deliberation.…”

Section: Discussionmentioning

confidence: 99%

“…Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became known to cause the highly contagious coronavirus disease 2019 (COVID- 19), the World Health Organization (WHO) declared this infection a pandemic on 11 March 2020. [1] Many governments implemented stringent policies such as lockdown of cities, social distancing restrictions, quarantine requirements for travellers and isolation of patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Discharging coronavirus disease 2019 (COVID-19) patients with faecal viral shedding and prolonged hospitalisation

Duque

Mak²,

Wong³

et al. 2020

JHA

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Discharging coronavirus disease 2019 (COVID-19) patients with faecal viral shedding and prolonged hospitalisation

Duque

Mak²,

Wong³

et al. 2020

JHA

View full text Add to dashboard Cite

show abstract

“…Children are less able to control their secretions and maintain social distancing. Children nasopharyngeal swab at day 14, although whether this represents viable virus is unclear [20,26,27]. Importantly, detection of viral RNA in stool raises the possibility of SARS-CoV-2 fecal-oral transmission particularly to caregivers [27][28][29].…”

Section: The Role Of Children In Community Transmission and Communitymentioning

confidence: 99%

“…Children nasopharyngeal swab at day 14, although whether this represents viable virus is unclear [20,26,27]. Importantly, detection of viral RNA in stool raises the possibility of SARS-CoV-2 fecal-oral transmission particularly to caregivers [27][28][29]. Obviously substantial risk exists for family and household members, but also is substantial for other critical adult members of society such as grocery workers, teachers, daycare providers, and healthcare providers who have frequent contact with children.…”

Section: The Role Of Children In Community Transmission and Communitymentioning

confidence: 99%

The Importance of Advancing Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Children

Kao

Orenstein

Anderson

2020

Clinical Infectious Diseases

View full text Add to dashboard Cite

Abstract While the role of children in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains to be defined, children likely play an important role based on our knowledge of other respiratory viruses. Children are more likely to be asymptomatic or have milder symptoms and less likely to present for healthcare and be tested for SARS-CoV-2. Thus, our current estimates are likely under-representative of the true burden of SARS-CoV-2 in children. Given the potential direct benefit of a SARS-CoV-2 vaccine in children and the substantial indirect benefit through community protection, or “herd immunity,” we argue that planning and implementation of SARS-CoV-2 vaccines should include children. Furthermore, community protection occurred after widespread implementation of prior childhood vaccines against Streptococcus pneumoniae, rubella, and rotavirus. We detail considerations for vaccine clinical trials, potential barriers to the implementation of widespread vaccination and argue why children would be an ideal target population for vaccination.

show abstract

“…The pediatric literature available at publication date was reviewed, including overall 13 children affected by SARS‐CoV‐2 infection with a positive RT‐PCR on the stool and/or rectal swab. Authors suggest that negativity in both naso‐pharyngeal and stool samples might be a standard requirement for the cessation of mandatory isolation 10 …”

Section: Is Fecal‐oral Transmission Possible?mentioning

confidence: 99%

Gastrointestinal involvement in children with SARS‐COV‐2 infection: An overview for the pediatrician

Chiappini

Licari

Motisi

et al. 2020

Pediatric Allergy Immunology

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), associated with the ongoing coronavirus disease 2019 (COVID-19) pandemic, is spreading at a remarkable high rate, with more than 5 million subjects infected worldwide. Children represented approximately 2% of all cases. 1 The available data suggest that mild forms are more frequent in children than adults, and the percentage of severe cases, requiring admission to intensive care unit and/ or mechanical ventilation, accounts for about 1% of overall pediatric cases. 1 Few deaths have also been reported. 1 However, it is under debate whether this low percentage is due to lower susceptibility to infection among children with respect to adults or similar infection rates but higher proportions of asymptomatic cases. Since children with no symptoms or paucisymptomatic forms are less likely to be tested, exact population denominators are absent, and accurate estimates cannot be calculated. The proportion of various symptoms reported in pediatric case series varies, and it is also affected by the definition of the case, the number of diagnostic tests performed, and the study setting. A recent systematic review, including 18 studies and 1065 children, showed that the most frequently reported symptoms are cough, fever, pharyngitis, and rhinorrhea, with varying percentages among studies. 1 Other frequently observed symptoms were headaches, myalgia, rash, conjunctivitis, syncopal episodes, and gastrointestinal manifestations such as vomiting, diarrhea, abdominal pain, and difficulty in feeding. Kawasaki-like syndrome, probably representing a post-infectious inflammatory syndrome, is also reported. Hereby, we review and discuss the available literature regarding the gastrointestinal involvement in children with SARS-CoV-2 infection.

show abstract

Dynamic Viral Severe Acute Respiratory Syndrome Coronavirus 2 RNA Shedding in Children: Preliminary Data and Clinical Consideration from a Italian Regional Center

Cited by 34 publications

References 14 publications

Discharging coronavirus disease 2019 (COVID-19) patients with faecal viral shedding and prolonged hospitalisation

Discharging coronavirus disease 2019 (COVID-19) patients with faecal viral shedding and prolonged hospitalisation

The Importance of Advancing Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Children

Gastrointestinal involvement in children with SARS‐COV‐2 infection: An overview for the pediatrician

Contact Info

Product

Resources

About