This paper proposes a fast integral terminal sliding mode (ITSM) control method for a cascaded nonlinear dynamical system with mismatched uncertainties. Firstly, an integral terminal sliding mode surface is presented, which not only avoids the singularity in the traditional terminal sliding mode, but also addresses the mismatched problems in the nonlinear control system. Secondly, a new ITSM controller with finite convergence time based on the backstepping technique is derived for a cascaded nonlinear dynamical system with mismatched uncertainties. Thirdly, the convergence time of ITSM is analyzed, whose convergence speed is faster than those of two nonsingular terminal sliding modes. Finally, simulation results are presented in order to evaluate the effectiveness of ITSM control strategies for mismatched uncertainties.