Dynamical decoupling methods in nanoscale NMR

Munuera-Javaloy, C.; Puebla, Ricardo; Casanova, Jorge

doi:10.1209/0295-5075/ac0ed1

Cited by 14 publications

(9 citation statements)

References 84 publications

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“…This is a particularly powerful quantum device, as it enables detection and control of nearby nuclear spins with nanoscale resolution [15]. Applications of the device are, e.g., the precise determination of the structure and dynamics of nuclear ensembles such as proteins [16], finding inter-label distances (via, e.g., Bayesian analysis of the NV response) in electronically labelled biomolecules [17], and the exploration of bespoke microwave (MW) sequences that efficiently transfer NV center polarization to the nuclear environment. Hyperpolarization (i.e.…”

Section: Introductionmentioning

confidence: 99%

Co-Design quantum simulation of nanoscale NMR

Algaba¹,

Mario²,

Munuera-Javaloy³

et al. 2022

Preprint

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Quantum computers have the potential to efficiently simulate the dynamics of nanoscale NMR systems. In this work we demonstrate that a noisy intermediate-scale quantum computer can be used to simulate and predict nanoscale NMR resonances. In order to minimize the required gate fidelities, we propose a superconducting application-specific Co-Design quantum processor that reduces the number of SWAP gates by over 90% for chips with more than 20 qubits. The processor consists of transmon qubits capacitively coupled via tunable couplers to a central co-planar waveguide resonator with a quantum circuit refrigerator (QCR) for fast resonator reset. The QCR implements the nonunitary quantum operations required to simulate nuclear hyperpolarization scenarios.

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Section: Introductionmentioning

confidence: 99%

Co-Design quantum simulation of nanoscale NMR

Algaba¹,

Mario²,

Munuera-Javaloy³

et al. 2022

Preprint

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“…They can be initialized and read out using laser light in the visible spectrum, thereby removing thermal fluctuations from the measurement process [14][15][16]. Moreover, NV hyperfine states can be manipulated with microwave radiation in such a way that the NV couples coherently to nearby nuclear and electron spins while at the same time being decoupled from environmental fluctuations [17][18][19][20][21]. These concepts have enabled shal-lowly implanted NV centers to detect electron spins [22] and even nuclear spins [23,24] above the diamond surface with single-spin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Detection of Molecular Changes with Nitrogen-Vacancy Centers and Electron-Spin Labels.

Munuera-Javaloy

Puebla

D’Anjou³

et al. 2022

Preprint

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We present a protocol that detects molecular conformational changes with two nitroxide electron-spin labels and a nitrogen-vacancy (NV) center in diamond. More specifically, we demonstrate that the NV can detect en- ergy shifts induced by the coupling between electron-spin labels. The protocol relies on the judicious application of microwave and radiofrequency pulses in a range of parameters that ensures stable nitroxide resonances. Fur- thermore, we demonstrate that our scheme is optimized by using nitroxides with distinct nitrogen isotopes. We develop a simple theoretical model that we combine with Bayesian inference techniques to demonstrate that our method enables the detection of conformational changes in ambient conditions including strong NV dephasing rates as a consequence of the diamond surface proximity and nitroxide thermalization mechanisms. Finally, we counter-intuitively show that with our method the small residual effect of random molecular tumbling becomes a resource that can be exploited to extract inter-label distances.

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“…In particular, the use of newly-developed solid-state quantum sensors [11], such as NV centers in diamond [12], has enabled to interrogate ever smaller samples [13][14][15]. This has led to NMR experiments that provide unprecedented spatial resolutions, even to the limit of single molecule addressing [16][17][18]. In this regard, the benefits of operating at large magnetic fields are expected to carry on for NMR analysis of micro and nanoscale sized samples with quantum sensors.…”

mentioning

confidence: 99%

“…However, the spectral resolution of standard quantum sensing techniques is severely limited by the coherence time of the sensor. In the case of NV centers, this restriction leads to kHz resolutions even when the sensor is stabilised with dynamical decoupling techniques [19], leading to an insufficient record for useful chemical analysis.…”

mentioning

confidence: 99%

High-Resolution NMR Spectroscopy at Large Fields with Nitrogen Vacancy Centers

Munuera-Javaloy¹,

Tobalina²,

Casanova³

2022

Preprint

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Ensembles of nitrogen-vacancy (NV) centers are used as sensors to detect NMR signals from micron-sized samples at room temperature. In this scenario, the regime of large magnetic fields is especially interesting as it leads to a large nuclear thermal polarisation -thus, to a strong sensor response even in low concentration samples-while chemical shifts and J-couplings become more accessible. Nevertheless, this regime remains largely unexplored owing to the difficulties to couple NV-based sensors with high-frequency nuclear signals.In this work, we circumvent this problem with a method that maps the relevant energy shifts in the amplitude of an induced nuclear spin signal that is subsequently transferred to the sensor. This stage is interspersed with free-precession periods of the sample nuclear spins where the sensor does not participate. Thus, our method leads to high spectral resolutions ultimately limited by the coherence of the nuclear spin signal.

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Dynamical decoupling methods in nanoscale NMR

Cited by 14 publications

References 84 publications

Co-Design quantum simulation of nanoscale NMR

Co-Design quantum simulation of nanoscale NMR

Detection of Molecular Changes with Nitrogen-Vacancy Centers and Electron-Spin Labels.

High-Resolution NMR Spectroscopy at Large Fields with Nitrogen Vacancy Centers

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