Dynamical modulation of theta-gamma coupling during REM sleep

Abstract

189 wordsMain text: ~3400 words peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/169656 doi: bioRxiv preprint first posted online Sep. 22, 2017; 2 Theta phase modulates gamma amplitude during spatial navigation and rapid eye movement sleep (REMs). Although the REMs theta rhythm has been linked to spatial memory consolidation, the underlying mechanism remains unclear. We investigate dynamics of thetagamma interactions across multiple frequency and temporal scales in simultaneous recordings from hippocampal CA3, CA1, subiculum, and parietal cortex. We show that theta phase significantly modulates three distinct gamma bands during REMs, dynamically. Interestingly, we further show that theta-gamma coupling swings between different hippocampal and cortical structures during REMs and tends to increase over a single REMs episode. Comparing to active wake, theta-gamma coupling during REMs is significantly increased for subicular and cortical, but not for CA3 and CA1, recordings. Finally, optogenetic silencing of septohippocampal GABAergic projections significantly impedes both theta-gamma coupling and theta phase coherence, two neural mechanisms of working and long-term memory, respectively. Thus, we show that theta-gamma coupling and theta phase coherence are highly modulated during single REMs episode and propose that theta-gamma coupling provides a predominant mechanism for information processing within each brain region, while the orchestrated nature of coupling activity establishes a specific phase-space coding of information during sleep.peer-reviewed)

Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable Gclm−/− mice

“…To assess this, we estimated the long-range modulation of the amplitude of spindle oscillations in one region of the TC networks by the phase of slow waves in a distant but connected TC area. Such phase-amplitude coupling (PAC) has been associated with cognitive and sensory processing in humans [ 99 , 100 ] and rodents [ 101 – 104 ] and with altered procedural and emotional processing in SZ patients [ 105 – 107 ]. PAC analysis revealed an enhanced SW-spindle oscillation in non-sensory TC networks (TRN - AD, ACC - AD) and within cortico-cortical networks (EEG front - EEG par ; ACC - Brr) of Gclm KO during SR.…”

Deficient thalamo-cortical networks dynamics and sleep homeostatic processes in a redox dysregulation model relevant to schizophrenia

“…We next quantified the phase amplitude coupling (PAC) reflects oscillation synchrony associated with cognitive and sensory processing in humans 52,53 and rodents [54][55][56] possibly associated with altered procedural and emotional processing in SZ patients [57][58][59] . Here, we assigned directionality on the modulation of two different brain areas by determining PAC between cortico-cortical (ACC-BRR), higher order (ACC-AD), intra-thalamic (TRN-AD) and sensory TC (VPL-Brr) pairs (Figure 4A).…”

Theta Phase Entrainment of Single-Cell Spiking in Rat Somatosensory Barrel Cortex and Secondary Visual Cortex Is Enhanced during Multisensory Discrimination Behavior

“…The rodent hippocampal local field potential expresses prominent theta oscillations (6-12 Hz) during awake behaviors such as locomotion (Kropff et al, 2021;Sinnamon, 2006), whisking during object sampling (Grion et al, 2016), orienting behaviors (Buzsáki, 2009;Whishaw & Vanderwolf, 1973) and REM sleep (Bandarabadi et al, 2019;Buzsáki, 2009). Hippocampal theta oscillations are generated through synchronized synaptic input from the medial septal area (Quirk et al, 2021;Brandon et al, 2014) and represent the coordinated activity of neural ensembles (Buzsáki et al, 2012;Einevoll et al, 2013).…”