Dynamically crosslinked polydimethylsiloxane-based polyurethanes with contact-killing antimicrobial properties as implantable alloplasts for urological reconstruction

Sharma, Swati; Mandhani, Anil; Bose, Suryasarathi; Basu, Bikramjit

doi:10.1016/j.actbio.2021.04.055

Cited by 21 publications

(29 citation statements)

References 72 publications

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“…The doublet peak in the range ∼1700–1730 cm –1 is the characteristic of the carbonyl group, which is absent in the PVDF/BT composite. The band corresponding to the N–H stretching frequency of the amide group was observed at ∼3300 cm –1 in neat TPU . The distinct broadening of the NH peak was observed in the higher frequency regime of 3000–3800 cm –1 (Figure e).…”

Section: Resultsmentioning

confidence: 88%

“…The band corresponding to the N−H stretching frequency of the amide group was observed at ∼3300 cm −1 in neat TPU. 24 The distinct broadening of the NH peak was observed in the higher frequency regime of 3000−3800 cm −1 (Figure 1e). The IR bands at ∼1530 and ∼1415 cm −1 are characteristic of C−N and CH 3 bending vibrations, respectively.…”

Section: Resultsmentioning

confidence: 90%

“…PVDF-based implants have been reported to be biocompatible in several earlier studies, in vivo . , The tailored electroactive properties of PVDF composites have been demonstrated to induce neurogenesis and osteogenesis of stem cells. , On the other hand, thermoplastic polyurethane (TPU) is a class of elastomer comprising soft and hard segments in the chain that show tensile and tear strengths with shock-resistance properties . TPU-based composites have been primarily investigated for wound healing, urological implants, and vascular grafts. − …”

Section: Introductionmentioning

confidence: 99%

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Functionalized Fluoropolymer-Compatibilized Elastomeric Bilayer Composites for Osteochondral Repair: Unraveling the Role of Substrate Stiffness and Functionalities

Panda

Basu

2021

ACS Appl. Bio Mater.

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The osteochondral lesions and osteoarthritis-related complications continue to be clinically relevant challenges to be addressed by the biomaterials community. Hydrogel-based scaffolds have been widely investigated to enhance osteochondral regeneration, but the inferior mechanical properties together with poor functional stability are the major constraints in their clinical translation. The development of osteochondral implants with natural tissue-mimicking mechanical properties remains largely unexplored. In this perspective, the present study demonstrates a strategy to develop a bilayer osteochondral implant with an elastically stiff composite (poly(vinylidene difluoride)-reinforced BaTiO3, PVDF/BT) and elastically compliant composite (maleic anhydride-functionalized PVDF/thermoplastic polyurethane/BaTiO3, m-PVDF/TPU/BT). The compositional variation in polymer composites allowed the elastic modulus of the hybrid bilayer construct to vary from ∼2 GPa to ∼90 MPa, which enabled a better understanding of the substrate-stiffness-dependent cellular behavior and maturation of preosteoblasts and chondrocytes. The cellular functionalities on PVDF-based polymer matrices have been benchmarked against ultrahigh-molecular-weight polyethylene (UHMWPE), which is clinically used for a wide spectrum of orthopedic applications. The increased alkaline phosphatase (ALP) activity, collagen synthesis, and matrix mineralization confirmed the early differentiation of preosteoblasts on the PVDF/BT matrix with subchondral bone-like mechanical properties. On the contrary, the upregulated chondrogenic functionalities were recorded on m-PVDF/TPU/BT with an elevated level of collagen content, glycosaminoglycans, and proteoglycans. Emphasis has been laid on probing the regulation of the osteochondral behavior using tailored substrate stiffness and functionalities using compatibilized fluoropolymer-based elastomeric composites. Taken together, the results of this work conclusively establish the efficacy of the hybrid bilayer composite with natural tissue-mimicking mechanical properties for the functional repair of osteochondral defects.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Functionalized Fluoropolymer-Compatibilized Elastomeric Bilayer Composites for Osteochondral Repair: Unraveling the Role of Substrate Stiffness and Functionalities

Panda

Basu

2021

ACS Appl. Bio Mater.

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“…The successful integration of varying contents of PDMS within the molten polyurethane matrix has been reported. The antimicrobial composition has been demonstrated to support the growth of the mitochondrially viable and interconnected murine fibroblasts over 7 days in culture [56].…”

Section: Synthetic Scaffoldsmentioning

confidence: 99%

Bladder Substitution: The Role of Tissue Engineering and Biomaterials

2021

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Tissue engineering could play a major role in the setting of urinary diversion. Several conditions cause the functional or anatomic loss of urinary bladder, requiring reconstructive procedures on the urinary tract. Three main approaches are possible: (i) incontinent cutaneous diversion, such as ureterocutaneostomy, colonic or ileal conduit, (ii) continent pouch created using different segments of the gastrointestinal system and a cutaneous stoma, and (iii) orthotopic urinary diversion with an intestinal segment with spherical configuration and anastomosis to the urethra (neobladder, orthotopic bladder substitution). However, urinary diversions are associated with numerous complications, such as mucus production, electrolyte imbalances and increased malignant transformation potential. In this context, tissue engineering would have the fundamental role of creating a suitable material for urinary diversion, avoiding the use of bowel segments, and reducing complications. Materials used for the purpose of urinary substitution are biological in case of acellular tissue matrices and naturally derived materials, or artificial in case of synthetic polymers. However, only limited success has been achieved so far. The aim of this review is to present the ideal properties of a urinary tissue engineered scaffold and to examine the results achieved so far. The most promising studies have been highlighted in order to guide the choice of scaffolds and cells type for further evolutions.

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“…Silicones, poly(urethanes), and poly(acrylates) are commonly used for such implants. In the case of monolithic implants, the drug is homogeneously dispersed within the polymer, whereas reservoir-type implants contain a compact drug core with some sort of polymer membrane around it that controls diffusion and the release of the pharmacological compound [306][307][308][309].…”

Section: May the Force Be With You: Mt And Its Implications For Periodontal Regenerationmentioning

confidence: 99%

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

et al. 2021

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Among oral tissues, the periodontium is permanently subjected to mechanical forces resulting from chewing, mastication, or orthodontic appliances. Molecularly, these movements induce a series of subsequent signaling processes, which are embedded in the biological concept of cellular mechanotransduction (MT). Cell and tissue structures, ranging from the extracellular matrix (ECM) to the plasma membrane, the cytosol and the nucleus, are involved in MT. Dysregulation of the diverse, fine-tuned interaction of molecular players responsible for transmitting biophysical environmental information into the cell’s inner milieu can lead to and promote serious diseases, such as periodontitis or oral squamous cell carcinoma (OSCC). Therefore, periodontal integrity and regeneration is highly dependent on the proper integration and regulation of mechanobiological signals in the context of cell behavior. Recent experimental findings have increased the understanding of classical cellular mechanosensing mechanisms by both integrating exogenic factors such as bacterial gingipain proteases and newly discovered cell-inherent functions of mechanoresponsive co-transcriptional regulators such as the Yes-associated protein 1 (YAP1) or the nuclear cytoskeleton. Regarding periodontal MT research, this review offers insights into the current trends and open aspects. Concerning oral regenerative medicine or weakening of periodontal tissue diseases, perspectives on future applications of mechanobiological principles are discussed.

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Dynamically crosslinked polydimethylsiloxane-based polyurethanes with contact-killing antimicrobial properties as implantable alloplasts for urological reconstruction

Cited by 21 publications

References 72 publications

Functionalized Fluoropolymer-Compatibilized Elastomeric Bilayer Composites for Osteochondral Repair: Unraveling the Role of Substrate Stiffness and Functionalities

Functionalized Fluoropolymer-Compatibilized Elastomeric Bilayer Composites for Osteochondral Repair: Unraveling the Role of Substrate Stiffness and Functionalities

Bladder Substitution: The Role of Tissue Engineering and Biomaterials

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

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