Dynamically scaled phantom phase contrast MRI compared to true‐scale computational modeling of coronary artery flow

Beier, Susann; Ormiston, John A.; Webster, Mark; Cater, John; Norris, Stuart; Medrano-Gracia, Pau; Young, Alistair A.; Cowan, Brett R.

doi:10.1002/jmri.25240

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…Advancements in the motion and driving subsystem has enabled both steady state or pulsatile flow to be used, whereby a pulsatile flow setup was previously used to closely mimic physiological blood flow fluctuations of the cardiac cycle. 138 Incorporation of different sized valves and compliance chambers may replicate physiological impedance, and the choice of fluid used offers control over shear-thinning and thickening properties 12 as a means of evaluating the performance of various functional models even on different scales. Example applications include total artificial hearts, aortic and mitral valves, and blood vessels.…”

Section: Milestone Applications Of 3d Cardiovascular Printingmentioning

confidence: 99%

3D Printing for Cardiovascular Applications: From End-to-End Processes to Emerging Developments

et al. 2021

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Abstract3D printing as a means of fabrication has seen increasing applications in medicine in the last decade, becoming invaluable for cardiovascular applications. This rapidly developing technology has had a significant impact on cardiovascular research, its clinical translation and education. It has expanded our understanding of the cardiovascular system resulting in better devices, tools and consequently improved patient outcomes. This review discusses the latest developments and future directions of generating medical replicas (‘phantoms’) for use in the cardiovascular field, detailing the end-to-end process from medical imaging to capture structures of interest, to production and use of 3D printed models. We provide comparisons of available imaging modalities and overview of segmentation and post-processing techniques to process images for printing, detailed exploration of latest 3D printing methods and materials, and a comprehensive, up-to-date review of milestone applications and their impact within the cardiovascular domain across research, clinical use and education. We then provide an in-depth exploration of future technologies and innovations around these methods, capturing opportunities and emerging directions across increasingly realistic representations, bioprinting and tissue engineering, and complementary virtual and mixed reality solutions. The next generation of 3D printing techniques allow patient-specific models that are increasingly realistic, replicating properties, anatomy and function.

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Section: Milestone Applications Of 3d Cardiovascular Printingmentioning

confidence: 99%

3D Printing for Cardiovascular Applications: From End-to-End Processes to Emerging Developments

et al. 2021

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“…Both a Newtonian and a non-Newtonian fluid was used experimentally. The experimental and numerical methods have been previously described in [5] and [8] and are summarized here briefly.…”

Section: Methodsmentioning

confidence: 99%

“…Whilst further developments in this field are exciting, intermediate assessments are warranted to build the foundation and insights informing such clinical implementation. The present study may contribute to such efforts and future blood flow studies may use in vitro dynamic scaling to overcome current resolution limitations with noninvasive imaging including 4D flow MRI [5].…”

Section: Patient-specific Considerationmentioning

confidence: 98%

“…The image stack was segmented by an experienced analyst using the seed growth method in Osirix (v. 4.1.2) and the CMIV CTA plug-in to generate the vessel centerlines [11]. The lumen was smoothed using Poisson surface reconstruction, cut and rendered and extended in the open-source VMTK software (Vascular modelling tool kit, www.vmtk.org) as detailed in an earlier publication [5]. The virtual geometry was then imported into AutoCAD Inventor (2016, AutoDesk, SanRafael, CA, USA).…”

Section: A Left Main Coronary Geometriesmentioning

confidence: 99%

“…MRI has not been *This work was financially supported by the Auckland Charitable Heart Trust, the Auckland Medical Research Foundation (AMRF) and the Auckland Academic Health Alliance (AAHA applied to coronary flow before because of limited temporal and spatial resolution. Previously we successfully used dynamically scaled in vitro coronary blood flow experiments to over-come these imaging limitations [5]. In this study, we explore if the same methodology is sufficiently adequate to capture changes to blood flow on the micro scale that are a result of stents in coronary arteries.…”

Section: Introductionmentioning

confidence: 99%

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Towards validating stent induced micro flow patterns in left main coronary artery bifurcations

Masoud-Ansari¹,

Ormiston

Webster

et al. 2019

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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We investigated if blood flow changes induced through the presence of a stent could be detected using in vitro dynamically scaled 4D Phase-Contrast Magnetic Resonance Imaging (PC-MRI). Using idealized and patient-specific left main coronary artery bifurcations, we 3D-printed the dynamically large scaled geometries and incorporated them into a flow circuit for non-invasive acquisition with a higher effective spatial resolution. We tested the effects of using non-Newtonian and Newtonian fluids for the experiment. We also numerically simulated the same geometries in true scale for comparison using computational fluid dynamics (CFD). We found that the experimental setup increased the effective spatial resolution enough to reveal stent induced blood flow changes close to the vessel wall. Non-Newtonian fluid replicated all of the flow field well with a strong agreement with the computed flow field (R 2 > 0.9). Fine flow structures were not as prominent for the Newtonian compared to non-Newtonian fluid consideration. In the patient-specific geometry, arterial non-planarity increased the difficulty to capture the near wall slow velocity changes. Findings demonstrate the potential to dynamically scale in vitro 4D MRI flow acquisition for micro blood flow considerations.

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Vascular Hemodynamics with Computational Modeling and Experimental Studies

Beier

Ormiston

Webster

et al. 2017

Computing and Visualization for Intravascular Imaging and Computer-Assisted Stenting

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Dynamically scaled phantom phase contrast MRI compared to true‐scale computational modeling of coronary artery flow

Cited by 10 publications

References 34 publications

3D Printing for Cardiovascular Applications: From End-to-End Processes to Emerging Developments

3D Printing for Cardiovascular Applications: From End-to-End Processes to Emerging Developments

Towards validating stent induced micro flow patterns in left main coronary artery bifurcations

Vascular Hemodynamics with Computational Modeling and Experimental Studies

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