2020
DOI: 10.1186/s13662-019-2438-0
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Dynamics analysis of a delayed virus model with two different transmission methods and treatments

Abstract: In this paper, a delayed virus model with two different transmission methods and treatments is investigated. This model is a time-delayed version of the model in (Zhang et al. in Comput. Math. Methods Med. 2015:758362, 2015. We show that the virus-free equilibrium is locally asymptotically stable if the basic reproduction number is smaller than one, and by regarding the time delay as a bifurcation parameter, the existence of local Hopf bifurcation is investigated. The results show that time delay can change th… Show more

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Cited by 580 publications
(93 citation statements)
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“…In addition to the bilinear incidence model considered in this paper, nonbilinear model with saturation incidence should be employed in the further study [35]. Besides, other important factors such as immune activation delays [36][37][38]48], stochastic effects [39,40,49], and impulsive perturbations [41,42,50] can be considered in the modelling of the tumor immune system. e tumor immune response dynamics in vivo is very complex and not well understood primarily because the measurements of the necessary parameters are difficult in vivo [43].…”
Section: Complexitymentioning
confidence: 99%
“…In addition to the bilinear incidence model considered in this paper, nonbilinear model with saturation incidence should be employed in the further study [35]. Besides, other important factors such as immune activation delays [36][37][38]48], stochastic effects [39,40,49], and impulsive perturbations [41,42,50] can be considered in the modelling of the tumor immune system. e tumor immune response dynamics in vivo is very complex and not well understood primarily because the measurements of the necessary parameters are difficult in vivo [43].…”
Section: Complexitymentioning
confidence: 99%
“…Eco-epidemiological models are also considered to describe the coronavirus pandemic that describes the real phenomena (Gao et al. 2020a , e ). The pioneering work of Kermack and McKendrick ( 1927 ) has established a classical SIR model (susceptible, infectious, recovered model) with the idea of plankton disease to study how the population is influenced by infection.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, there are lots of works discussing the cell‐to‐cell infection mode. Among these works, Culshaw et al established a new viral model incorporating cell‐to‐cell infection with mass action incidence . Kouche and Ainseba introduced saturated incidence into the model proposed in Culshaw et al Komarova et al presented a viral model by incorporating cell‐free and cell‐to‐cell infections .…”
Section: Introductionmentioning
confidence: 99%