Dynamics and Clinical Evolution of Bacterial Gut Microflora in Extremely Premature Patients

Jacquot, Aurélien; Neveu, Dorine; Aujoulat, Fabien; Mercier, Grégoire; Marchandin, Hélène; Jumas‐Bilak, Estelle; Picaud, Jean‐Charles

doi:10.1016/j.jpeds.2010.09.007

Cited by 199 publications

(208 citation statements)

References 29 publications

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“…Studies of gut bacteria in preterm infants have been limited in subject and/or sample numbers (24,28,29), have used cross-sectional comparisons (30), or did not stratify extensively by gestational age at birth or age postconception (30)(31)(32)(33)(34)(35)(36). Our intensive and extensive dataset suggests that limited sampling in premature neonates is problematic because of very frequent alterations in population structure.…”

Section: Discussionmentioning

confidence: 99%

Patterned progression of bacterial populations in the premature infant gut

Rosa¹,

Warner

Zhou³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

483

524

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The authors note that on page 12527, left column, second full paragraph, line 7, "Sequences meeting the above criteria were further classified by the Ribosomal Database Project (RDP) Naive Bayesian Classifier version 2.5 using training set 9 (46) from phylum to genus level." should instead appear as "Sequences meeting the above criteria were further classified by the Ribosomal Database Project (RDP) Naive Bayesian Classifier version 2.2 using training set 6 (46) from phylum to genus level."www.pnas.org/cgi

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Section: Discussionmentioning

confidence: 99%

Patterned progression of bacterial populations in the premature infant gut

Rosa¹,

Warner

Zhou³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

483

524

View full text Add to dashboard Cite

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“…15,17,32 A narrowing spectrum of microflora presages the development of NEC. 15 Wang et al 33 demonstrated that preterm infants with NEC had a predominance of proteobacteria in the stool, and suggested that limited bacterial diversity and pathogenic bacterial predominance may contribute to the susceptibiity of premature infants to NEC.…”

Section: Discussionmentioning

confidence: 99%

Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis

Ferrara

DeLuca

et al. 2011

J Perinatol

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Objective: To determine whether an association exists between antenatal antibiotic exposure and incidence of necrotizing enterocolitis (NEC) in low birth weight infants.Study Design: A retrospective case-control study was performed on all infants with a diagnosis of NEC born at our institition between 1988 and 2006. Medical histories of all infants with a diagnosis of NEC XBell's stage IIA and matched controls without NEC were reviewed. Maternal and neonatal characteristics were compared using the Mantel-Haenszel chi-square procedure, and logistic regression models were constructed to account for confounding.Result: Clinical data for 97 matched pairs were analyzed. The adjusted odds ratio (OR) for antenatal exposure to ampicillin was significantly greater for infants who developed NEC (OR 2.3, 95% confidence interval 1.1, 4.8, P ¼ 0.003) than for control infants. Conclusion:Infants who developed NEC were more likely to have a history of in utero exposure to ampicillin in the immediate antepartum period than infants who did not develop NEC.

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“…These events lead to an increase in the prevalence of potentially pathogenic bacteria in the GI tract and less microbial diversity than full term infants [31][32][33] . The extent to which these features play a role in the development of cerebral palsy and subsequent autism are the subject of research and ongoing debate 34 .…”

Section: Brain-gut-microbiota Axis and Extremes Of Lifementioning

confidence: 99%

The Microbiome-Gut-Brain Axis in Health and Disease

Dinan

Cryan

2017

Gastroenterology Clinics of North America

797

525

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Type of publicationArticle (peer-reviewed) Abstract/SummaryGut microbes are capable of producing most neurotransmitters found in the human brain.While these neurotransmitters primarily act locally in the gut, modulating the enteric nervous system, evidence is now accumulating to support the view that gut microbes through multiple mechanisms can influence central neurochemistry and behavior. This has been described as a fundamental paradigm shift in neuroscience. Bifidobacteria for example can produce and increase plasma levels of the serotonin precursor tryptophan, which is fundamental in regulating mood, appetite and gastrointestinal function. CertainLactobacilli have been shown to produce gamma-aminobutyric acid (GABA) and to alter brain GABA receptor expression and behavior. IBS is regarded as the prototypic disorder of the brain-gut-microbiota axis which can be responsive to probiotic therapy.

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Dynamics and Clinical Evolution of Bacterial Gut Microflora in Extremely Premature Patients

Cited by 199 publications

References 29 publications

Patterned progression of bacterial populations in the premature infant gut

Patterned progression of bacterial populations in the premature infant gut

Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis

The Microbiome-Gut-Brain Axis in Health and Disease

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