Structural integrity and human safety are topics of high interest, especially in the light of technological advancements that are currently leading to implementations of smart cities. This article presents the design methodology of a modal controller for seismic vibration, when equipping building with smart devices, like magnetorheological dampers, which are inherently nonlinear. A formal-heuristic hybrid multiloop configuration is thus adopted, making use of both the maneuverability of conventional controllers and the intelligent complexity of evolutionary optimization. For validation purposes, an optimal controller is also implemented for the same structure. The two control systems’ performances are analyzed and compared, taking into account two types of earthquake disturbances and significant mass variation throughout the structure.