Dynamics of activities of matrix metalloproteinases-9 and -2, and the tissue inhibitors of MMPs in fetal fluid compartments during gestation and at parturition in the mare

Oddsdóttir, Charlotta; Riley, Simon C.; Leask, Rosemary; Shaw, Darren; Aurich, Christine; Palm, Franziska; Fowden, Abigail L.; Ricketts, S. W.; Watson, E.D.

doi:10.1016/j.theriogenology.2010.11.023

Cited by 11 publications

(12 citation statements)

References 31 publications

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“…The higher fluid concentration of MMP‐8 in the cervical region may increase the likelihood that membrane rupture will occur closer to the lower pole of the uterus. This accumulation of MMP in amniotic fluid is also reported in mares, which show higher proMMP‐9 concentrations when approaching normal foaling followed by lower concentrations during foaling (Oddsdottir et al, ), and in rats, which exhibit a steady rise in MMP‐2 activity within the visceral yolk‐sac placenta between Days 18–21 of pregnancy (Lei et al, ).…”

Section: Roles Of the Mmp System During Fetal Membrane Rupturementioning

confidence: 56%

“…The probability of preterm birth is increased when the activities of MMPs and their inhibitors are thrown out of balance. For example, the pattern of MMP‐2, MMP‐9, and TIMP‐2 are analogous during preterm birth and foaling in mares, with lower MMP‐9 activity in amniotic and allantoic fluids and higher MMP‐2 and TIMP‐2 abundance—albeit the net levels are lower before preterm birth than term delivery (Oddsdottir et al, ). Similarly, when extracted with high concentrations of sodium dodecyl sulfate, the abundance of pro‐ and mature MMP‐2 is higher in the human amnion during term labor than during preterm birth (Yonemoto et al, ).…”

Section: Roles Of the Mmp System During Fetal Membrane Rupturementioning

confidence: 99%

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Roles and regulation of the matrix metalloproteinase system in parturition

Geng

Huang

Jiang

2016

Molecular Reproduction Devel

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SUMMARYSignificant tissue destruction, repair, and remodeling are involved in parturition, which involves fetal membrane rupture, cervical ripening, and uterine contraction and its subsequent involution. Extracellular matrix degradation and remodeling by proteolytic enzymes, such as matrix metalloproteinases (MMPs), are required for the final steps of parturition. MMPs participate in physiological degradation and remodeling through their proteolytic activities on specific substrates, and are balanced by the action of their inhibitors. Disruption to this balance can result in pathological stress that ends with preterm or post-term birth or pre-eclampsia. In this review, we examine the roles and regulation of the MMP system in physiological and pathological labor, and propose a model that illustrates the mechanisms by which the MMP system contributes to these processes.Mol. Reprod. Dev. 83: 276À286,

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Section: Roles Of the Mmp System During Fetal Membrane Rupturementioning

confidence: 56%

Section: Roles Of the Mmp System During Fetal Membrane Rupturementioning

confidence: 99%

Roles and regulation of the matrix metalloproteinase system in parturition

Geng

Huang

Jiang

2016

Molecular Reproduction Devel

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“…Zgodnie z hipotezą Robertsa (58), po przerwaniu pępowiny zanika krążenie w obrębie części płodowej łożyska i kosmki błon płodowych obkurczają się i zmniejszają swoją objętość. Ten proces wymaga przebudowy macierzy zewnątrzkomórkowej (extracellular matrix, ECM) (36), która następuje za pośrednictwem enzymów proteolitycznych, metaloproteinaz (matrix metalloproteinases, MMP) (9,13,38,42,47,71,77).…”

Section: Ryc 1 Ekspresja Białka Mhc-i W Tkankach łOżyska Klaczyunclassified

The role of placental immunological, pro-inflammatory, and proteolytic factors in the process of fetal membrane expulsion in mares

Rapacz-Leonard¹

2021

Medycyna Weterynaryjna

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The placenta is a temporary organ necessary for prenatal life and the development of eutherian mammals. In the mare it should be expelled within 3 hours of expulsion of the fetus. A delay in its separation can have serious or fatal consequences for mares. The preparation of the mare for the expulsion of the fetal membranes most likely requires immunological interactions between placental antigen and the mare’s immune system. The latest results suggest that fetal membrane retention is related to disorders of inflammatory processes in the placenta, including a lower expression of prostaglandin endoperoxide synthase-2. These disorders in the pro-inflammatory response and disturbances in the activity of the proteolytic enzyme network may lead to adhesion between the fetal and the maternal parts of the placenta. The resulting adhesion may cause the fetal membranes to be thicker and less flexible, making them difficult to expel. Understanding the mechanism of placental retention may contribute to the development of effective methods to prevent and treat this condition.

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“…In mares, MMPs are present in amniotic and allantoic fluids throughout pregnancy and at parturition. Amniotic concentrations of MMP‐9 are high towards the end of gestation, but decline during labour, indicating that the tissue remodelling has already occurred by this time (Oddsdottir et al . 2011).…”

Section: Spontaneous Parturition At Termmentioning

confidence: 99%

Prostaglandins and the regulation of parturition in mares

Ousey

Fowden

2012

Equine Veterinary Journal

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Prostaglandins play an essential role during the perinatal period in the mare. Prostaglandin concentrations are low for the majority of pregnancy due to the regulatory action of progestagens on those enzymes responsible for metabolism of prostaglandins. Towards term, prostaglandin concentrations gradually increase, closely associated with upregulation of the fetal hypothalamo-pituitary-adrenal axis, stimulation of the prostaglandin synthesising enzyme PGHS-2 and changes in the ratio of progestagens and oestrogens. Recent evidence in the mare indicates that proinflammatory cytokines are key mediators of prostaglandin synthesis both at term parturition in healthy mares and at preterm parturition associated with placental infection. Prostaglandin concentrations rise substantially during active labour and decline after birth, associated with delivery of the placenta. During induced labour, prostaglandin concentrations are variable depending on the proximity to spontaneous parturition at term. Once the proinflammatory endocrine cascade is initiated, it is difficult to prevent active labour by administration of drugs that reduce prostaglandin concentrations in peripheral plasma. Further work is needed to establish the inter-relationships between prostaglandin production and other endocrine changes associated with labour at term and preterm in the mare.

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Dynamics of activities of matrix metalloproteinases-9 and -2, and the tissue inhibitors of MMPs in fetal fluid compartments during gestation and at parturition in the mare

Cited by 11 publications

References 31 publications

Roles and regulation of the matrix metalloproteinase system in parturition

Roles and regulation of the matrix metalloproteinase system in parturition

The role of placental immunological, pro-inflammatory, and proteolytic factors in the process of fetal membrane expulsion in mares

Prostaglandins and the regulation of parturition in mares

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