Dynamics of age changes of somatotropin concentration in blood plasma and morphometric parameters of laboratory female mice ovaries

Katelnikova, A.E.; Trofimets, E.I.; Матичин, А А; Фаустова, Н.М.; Gushchin, Ya.; Макарова, М.Н.

doi:10.29296/2618723x-2020-03-07

Лабораторные животные для научных исследований

2020

DOI: 10.29296/2618723x-2020-03-07

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Dynamics of age changes of somatotropin concentration in blood plasma and morphometric parameters of laboratory female mice ovaries

A.E. Katelnikova¹,

E.I. Trofimets²,

А А Матичин³

et al.

Abstract: Динамика изменений с возрастом концентрации соматотропина в плазме крови и морфометрических параметров яичников у самок лабораторных мышей А.Е. Кательникова 1 , кандидат медицинских наук, руководитель группы специфической токсикологии, Е.И. Трофимец 1 , токсиколог, А.А. Матичин 1 , фармаколог, Н.М. Фаустова 2 , кандидат химических наук, старший научный сотрудник группы фармакокинетики, Я.А. Гущин 3 , руководитель отдела гистологии и патоморфологии, ORCID 0000-0002-7656-991Х, М.Н. Макарова 3 , доктор медицински… Show more

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Effect of a sorbent composition based on aluminum oxide and polydimethylsiloxane on the reproductive system of <i>db/db</i> female mice with genetically determined obesity and type 2 diabetes mellitus

Dergacheva,

Michurina,

Ishchenko

et al. 2023

Acta biomedica scientifica

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Metabolic syndrome, obesity, type 2 diabetes mellitus are characterized by the accumulation of toxic metabolic products in the internal environment of the organism. The development of innovative medicines based on a sorbent matrix modified with biologically active molecules remains relevant. The sorbent composition from aluminum oxide and polydimethylsiloxane is considered promising. The aim of the study. To investigate the effect of the sorbent composition from aluminum oxide and polydimethylsiloxane on the uterus and ovaries of db/db mice with obesity and type 2 diabetes mellitus. Materials and methods. The sorbent composition (0.665 g/kg in 200 μl of distilled water) was administered to 14-week-old animals through an intragastric tube once a day for 7 days. The comparison groups were female rats injected with placebo (daily intragastrical administration of 200 µl of water for 7 days) and intact animals. Digital images of light-optical preparations stained with hematoxylin and eosin were processed using Image-Pro Plus 4.1 software. In the ovaries, the numerical density of primordial, primary, secondary follicles and corpus luteum was determined. The width of the uterus layers, the diameters of the blood and lymphatic vessels, the width of the interstitial fissures in both organs were measured. The statistical significance of differences was determined using the Mann – Whitney test. Results. In the myometrium and endometrium of the uterus of db/db mice, dilatation of arteries, veins, lymphatic vessels and edema were noted due to the accumulation of tissue fluid in the interstitium layers. There were no tertiary follicles in the ovaries. The introduction of the sorbent composition contributed to a decrease in the diameters of arteries, veins, lymphatic vessels of the uterus, a decrease in edema in both organs due to the narrowing of the prelymphatic slits, and stimulated an increase in the numerical density of secondary follicles. Conclusion. A corrective effect of the sorbent composition of aluminum oxide and polydimethylsiloxane on prelymphatic slits, blood and lymphatic vessels in the uterus and ovaries in db/db mice with obesity and type 2 diabetes mellitus was revealed.

show abstract

Effect of a sorbent composition based on aluminum oxide and polydimethylsiloxane on the reproductive system of <i>db/db</i> female mice with genetically determined obesity and type 2 diabetes mellitus

Dergacheva,

Michurina,

Ishchenko

et al. 2023

Acta biomedica scientifica

View full text Add to dashboard Cite

show abstract

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Dynamics of age changes of somatotropin concentration in blood plasma and morphometric parameters of laboratory female mice ovaries

Cited by 1 publication

References 13 publications

Effect of a sorbent composition based on aluminum oxide and polydimethylsiloxane on the reproductive system of <i>db/db</i> female mice with genetically determined obesity and type 2 diabetes mellitus

Effect of a sorbent composition based on aluminum oxide and polydimethylsiloxane on the reproductive system of <i>db/db</i> female mice with genetically determined obesity and type 2 diabetes mellitus

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