Dynamics of Albumin Synthetic Response to Intra-Abdominal Abscess in Patients with Gastrointestinal Fistula

ZhouBo,; RenJianan,; HanGang,; ChenYu,; AJiye,; GuGuosheng,; CHENJun,; WangGefei,; LiJieshou,

doi:10.1089/sur.2012.144

Cited by 8 publications

(10 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In postsurgical or septic children and adolescents, FSRs were high, but did not increase after nutrition support . In intestinal fistula patients with intra‐abdominal abscesses, serum albumin synthesis rate was found to be decreased . This does not exclude the possibility that in individuals with mild disease activity, nutrition support, especially including protein/amino acids, increases serum albumin synthesis.…”

Section: The Pathophysiology Underlying Hypoalbuminemiamentioning

confidence: 90%

“…77 In intestinal fistula patients with intra-abdominal abscesses, serum albumin synthesis rate was found to be decreased. 78 This does not exclude the possibility that in individuals with mild disease activity, nutrition support, especially including protein/amino acids, increases serum albumin synthesis. A change in the amount of serum albumin also is a function of its rate of breakdown.…”

Section: Hypoalbuminemia and Albumin Kineticsmentioning

confidence: 99%

See 1 more Smart Citation

Hypoalbuminemia: Pathogenesis and Clinical Significance

Soeters

Wolfe

Shenkin

2018

J Parenter Enteral Nutr

758

554

View full text Add to dashboard Cite

Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in the literature, there is still confusion regarding its pathogenesis and clinical significance. Inflammation increases capillary permeability and escape of serum albumin, leading to expansion of interstitial space and increasing the distribution volume of albumin. The half‐life of albumin has been shown to shorten, decreasing total albumin mass. These 2 factors lead to hypoalbuminemia despite increased fractional synthesis rates in plasma. Hypoalbuminemia, therefore, results from and reflects the inflammatory state, which interferes with adequate responses to events like surgery or chemotherapy, and is associated with poor quality of life and reduced longevity. Increasing or decreasing serum albumin levels are adequate indicators, respectively, of improvement or deterioration of the clinical state. In the interstitium, albumin acts as the main extracellular scavenger, antioxidative agent, and as supplier of amino acids for cell and matrix synthesis. Albumin infusion has not been shown to diminish fluid requirements, infection rates, and mortality in the intensive care unit, which may imply that there is no body deficit or that the quality of albumin “from the shelf” is unsuitable to play scavenging and antioxidative roles. Management of hypoalbuminaemia should be based on correcting the causes of ongoing inflammation rather than infusion of albumin. After the age of 30 years, muscle mass and function slowly decrease, but this loss is accelerated by comorbidity and associated with decreasing serum albumin levels. Nutrition support cannot fully prevent, but slows down, this chain of events, especially when combined with physical exercise.

show abstract

Section: The Pathophysiology Underlying Hypoalbuminemiamentioning

confidence: 90%

Section: Hypoalbuminemia and Albumin Kineticsmentioning

confidence: 99%

Hypoalbuminemia: Pathogenesis and Clinical Significance

Soeters

Wolfe

Shenkin

2018

J Parenter Enteral Nutr

758

554

View full text Add to dashboard Cite

show abstract

“…On the basis of the AA composition of acute-phase proteins and their increased synthesis by the liver during infection it has been hypothesised that demand for phenylalanine would increase ( 14 ) . Such increased demands may be counteracted by less production of serum albumin, as occurs in response to reduced intake ( 31 ) or certain infections ( 32 ) , although this can vary with stage of infection ( 33 ) . In the current study, it would appear that any additional needs for phenylalanine have been met either from increased mobilisation of tissue protein and/or from reduced hepatic catabolism.…”

Section: Discussionmentioning

confidence: 99%

Responses in whole-body amino acid kinetics to an acute, sub-clinical endotoxin challenge in lambs

et al. 2015

View full text Add to dashboard Cite

Some effects of parasitism, endotoxaemia or sepsis can be mitigated by provision of extra protein. Supplemented protein may encompass a metabolic requirement for specific amino acids (AA). The current study investigates a method to identify and quantify the amounts of AA required during inflammation induced by an endotoxin challenge. One of each pair of six twin sheep was infused in the jugular vein for 20 h with either saline (control) or lipopolysaccharide (LPS, 2 ng/kg body weight per min) from Escherichia coli. Between 12 and 20 h a mixture of stable isotope-labelled AA was infused to measure irreversible loss rates. From 16 to 20 h all sheep were supplemented with a mixture of unlabelled AA infused intravenously. Blood samples were taken before the start of infusions, and then continuously over intervals between 14 and 20 h. At 20 h the sheep were euthanised, and liver and kidney samples were taken for measurement of serine-threonine dehydratase (SDH) activity. LPS infusion decreased plasma concentrations of most AA (P < 0·05; P < 0·10 for leucine and tryptophan), except for phenylalanine (which increased P = 0·022) and tyrosine. On the basis of the incremental response to the supplemental AA, arginine, aspartate, cysteine, glutamate, lysine (tendency only), glycine, methionine, proline, serine and threonine were important in the metabolic response to the endotoxaemia. The AA infusion between 16 and 20 h restored the plasma concentrations in the LPS-treated sheep for the majority of AA, except for glutamine, isoleucine, methionine, serine and valine. LPS treatment increased (P < 0·02) SDH activity in both liver and kidney. The approach allows quantification of key AA required during challenge situations.Key words: Endotoxin lipopolysaccharide: Amino acids: Irreversible loss rate: Serine-threonine dehydratase: SheepThe protein and amino acid (AA) demands of animals for normal physiological states (e.g. growth, pregnancy and lactation) are now well characterised, especially for pigs and poultry (1) and with progress made in ruminants (2) . These requirements are altered, however, in response to injury, infection and parasitic challenge. In many cases, impact of these challenges can be ameliorated and the rate of recovery improved by provision of additional protein in the diet (3)(4)(5)(6) . Often, however, the amount of protein required is not known, with consequences for both animal performance and farm economics.More importantly, protein per se may not be required, but instead the metabolic responses to the challenge may increase the demand for specific AA. For example, practical and theoretical arguments have been presented for additional arginine in cardiovascular and pulmonary disorders (7)(8)(9)(10) , for cysteine (11) , leucine (12) and threonine (13) in sepsis, for glutamine in endotoxaemia (10) , and for phenylalanine to support acutephase protein synthesis (14) . In other situations, combinations of AA have been proposed (10,15,16) . Obviously different stages of injury, infection or recover...

show abstract

“…Therefore, unsaturated LPCs primarily associate with albumin instead of lipoproteins (32). Furthermore, a number of studies indicated that the rate of albumin degradation and albumin loss in tissue increased in patients with critical illnesses, such as sepsis (33)(34)(35). In addition, the concentration of albumin would return to normal values (32) as soon as the infection was controlled.…”

Section: Trend ------------------------------------------------------mentioning

confidence: 99%

Probiotic pre-administration reduces mortality in a mouse model of cecal ligation and puncture-induced sepsis

Chen

Gui

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. A number of clinical trials have demonstrated that the use of probiotics has the potential to prevent nosocomial infections. However, the mechanism underlying probiotic-induced anti-infection and sepsis remains to be investigated. In the present study, 200 µl/day of Lactobacillus rhamnosus GG (LGG) or normal saline (control) was orally administrated to 4-week-old C57BL6 mice 4 weeks prior to cecal ligation and puncture (CLP). A number of mice were sacrificed 24 h after CLP, and the remaining mice were used for survival studies. Ileum tissues were collected to evaluate the injury on the intestine. Blood samples were also obtained to investigate the changed metabolic pattern in mice that underwent different treatments using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). In the survival studies, the mortality of CLP-induced septic mice pretreated with LGG was significantly lower compared with untreated mice (P= 0.029). Ileum mucosal damage was evident in the control septic mice. Based on the data of UPLC-QTOF-MS, phosphatidylcholines were increased and lysophosphatidylcholines (LPCs) that contained polyunsaturated fatty acids were decreased in septic mice, whereas saturated fatty acid LPCs reveal no significant difference between septic and sham mice. In addition, the metabolic profile in the septic mice pretreated with LGG was much closer to that of sham mice compared with control septic mice. The results of the present study suggest that probiotic pre-administration reduces the mortality in septic mice by decreasing ileum mucosal damage, increasing the gut barrier integrity and altering global serum metabolic profiles.

show abstract

Dynamics of Albumin Synthetic Response to Intra-Abdominal Abscess in Patients with Gastrointestinal Fistula

Cited by 8 publications

References 35 publications

Hypoalbuminemia: Pathogenesis and Clinical Significance

Hypoalbuminemia: Pathogenesis and Clinical Significance

Responses in whole-body amino acid kinetics to an acute, sub-clinical endotoxin challenge in lambs

Probiotic pre-administration reduces mortality in a mouse model of cecal ligation and puncture-induced sepsis

Contact Info

Product

Resources

About