Dynamics of antibody response to CoronaVac vaccine

Fonseca, Marcela Helena Gambim; Souza, Tamiris de Fátima Goebel de; Araújo, Fernanda Montenegro de Carvalho; Andrade, Luiz Odorico Monteiro de

doi:10.1002/jmv.27604

Cited by 47 publications

(48 citation statements)

References 46 publications

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“…These antibodies were capable of neutralizing different variants of concern of SARS-CoV-2 7 . In a cohort of healthcare workers in Brazil, about 48% of participants of the study had prior history of SARS-CoV-2 infection at the time of receiving the first dose of CoronaVac, an inactivated whole SARS-CoV-2 vaccine 8 . Anti-spike antibodies measured by ELISA were about five-fold higher after one dose of CoronaVac in participants with prior COVID-19 infection and no further increase in antibodies was observed after the second dose of the vaccine 8 .…”

Section: Introductionmentioning

confidence: 99%

Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination

et al. 2022

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Many adults in India have received at least one dose of COVID-19 vaccine with or without a prior history SARS-CoV-2 infection. However, there is limited information on the effect of prior immunity on antibody response upon vaccination in India. As immunization of individuals continues, we aimed to assess whether pre-existing antibodies are further boosted by a single dose of BBV152, an inactivated SARS-CoV-2 vaccine, and, if these antibodies can neutralize SARS-CoV-2 Delta and Omicron variants. Here we show that natural infection during the second wave in 2021 led to generation of neutralizing antibodies against other lineages of SARS-CoV-2 including the Omicron variant, albeit at a significantly lower level for the latter. A single dose of BBV152 boosted antibody titers against the Delta and the Omicron variants but the antibody levels remained low against the Omicron variant. Boosting of antibodies showed negative correlation with baseline neutralizing antibody titers.

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Section: Introductionmentioning

confidence: 99%

Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination

et al. 2022

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“…In CoronaVac vaccination it was shown that after 6 months post-vaccination almost all HCW subjects has prooved a decreased antibody persistence 25 . AZD1222 (ChAdOx1) vaccination study has shown also an important decline in antibody levels in HCW, months after vaccination 26 .…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers

Zurac

Vlădan

Dincă

et al. 2022

Sci Rep

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Waning of the immune response upon vaccination in SARS-CoV-2 infection is an important subject of evaluation in this pandemic, mostly in healthcare workers (HCW) that are constantly in contact with infected samples and patients. Therefore, our study aimed to establish the specific humoral response of specific IgG and IgA antibodies upon vaccination, during the second year of pandemic and evaluating the booster shot with the same vaccine type. A group of 103 HCW with documented exposure to the virus were monitored for specific IgG and IgA levels prior to vaccination, after the first vaccination round, during the following 8 months and after the booster shot with the same vaccine type. After 8 months post-vaccination the humoral response in both IgG and IgA decreased, 2.4 times for IgG, and 2.7 times for IgA. Although the antibodies levels significantly decreased, no documented infection was registered in the group. After the booster shot, the entire group, displayed IgG increased levels, immediately after booster followed by the increase in specific IgA. IgG levels post-second round of vaccination are statistically higher compared to the first round, while IgA is restored at the same levels. Within the vaccination or booster routine for a multiple waves’ pandemic that is generating new virus variants, populational immunity remains an important issue for future implementation of prevention/control measures.

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“…Studies conducted on the vaccines with the inactivated virus yielded similar results. A study on 1,247 healthcare workers in Brazil showed that there was an increase in seropositivity rates after the first dose (88%), and an even higher seropositivity rate after the second dose (99%) (24).…”

Section: Discussionmentioning

confidence: 99%

“…Although vaccination rates were high across the study population, a decreasing trend in the seroprevalence was found over time after vaccination. After the development of an antibody response to the S protein of the virus, a decline in antibody levels has been observed after 3 months and after 6 months of the second dose (20,24,25). This may explain the decline in seroprevalence found in our results over time.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of SARS-CoV-2 antibodies within the community of a private tertiary university in the Philippines: a serial cross sectional study

Sumpaico-Tanchanco

et al. 2022

Preprint

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The antibody testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was used to detect the presence of antibodies in a private university setting. This serial cross-sectional study determined the seroprevalence of SARS-CoV-2 antibodies using qualitative and quantitative tests. Between June 2021 to December 2021, samples from 1,318 participants were tested, showing 47.80% of the study population yielding IgG antibodies to SARS-CoV-2 virus. A general increase in seroprevalence was observed from June to December 2021. However, a decreasing trend in IgG reactivity was found in vaccinated individuals over time. IgG antibody formation was observed across all brands of vaccines.

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Dynamics of antibody response to CoronaVac vaccine

Cited by 47 publications

References 46 publications

Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination

Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination

Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers

The prevalence of SARS-CoV-2 antibodies within the community of a private tertiary university in the Philippines: a serial cross sectional study

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