Dynamics of apoptosis in γ-irradiated lymphocytes and the CD21+CD27+ B-cell subset as a potential biodosimetric marker

Šinkorová, Zuzana; Zárybnická, Lenka; Matoskova, Lucie; Tichý, Aleš; Pejchal, Jaroslav; Sinkora, J

doi:10.1016/j.radmeas.2011.04.005

Cited by 3 publications

(1 citation statement)

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“…We and others have previouly shown that B-cells are the most radiosensitive lymhocyte population both in vitro and in vivo, 43,44 while apparent radiosensitivity of NK cells strongly differs under in vivo and in vitro conditions where this population of phylogenetically oldest lymhocytes exerts the lowest and higest reduction in relative numbers, respectively. 45,46 We have documented B-cells from our patient to be much more radioresistant than their counterparts in healthy individual in vitro.…”

Section: Review Of the Literaturementioning

confidence: 73%

Hypersensitivity to chemoradiation in FANCA carrier with cervical carcinoma—A case report and review of the literature

Sirák

Šinkorová

Šenkeříková

et al. 2015

Reports of Practical Oncology & Radiotherapy

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Although there are no standard guidelines for management of FA carriers with malignancies and reports about chemo- or radiosensitivity in this population are scarce; patients with FA-A heterozygosity may have a high rate of complications from chemo/radiotherapy. Up to now, an optimum method for the prediction of radiosensitivity and the best parameter has not been found. Clinical radioresponsiveness is unpredictable in FA carriers and there is a pressing need of new rapid and predictive in vitro assays of radiation responses. Until then, the treatment of FA carriers with malignancies should be individualized, with respect to potential hypersensitivity to ionizing radiation or cross-linking agents.

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Section: Review Of the Literaturementioning

confidence: 73%